Redox Regulation in Cardiovascular Diseases

Dear Colleagues,

Cardiovascular diseases (CVDs) remain the main cause of death worldwide. While numerous factors facilitate the onset of CVD, oxidative stress, caused by an imbalance between oxidants and antioxidants, is a major contributor. While oxygen gas is used in vascular cells to carry out their physiological functions, free radicals, including reactive oxygen species (ROS) and reactive nitrogen species (RNS), are generated either as side products or as important regulators themselves. These chemically highly reactive molecules, if left unrestricted, have the potential to modify proteins, lipids, and nucleic acids, which cause oxidative stress and cell damage. Therefore, oxidants reach physiological equilibrium with various antioxidant enzymes and molecules in a healthy body. However, a major challenge for vascular cells in maintaining the redox balance is that they often face a constantly changing surrounding environment (e.g., fluctuation of nutrients, hormones, mechanical forces, invading pathogens, etc.), which requires them to adapt to it in a timely manner. Recent findings suggest that maladaptation in redox status leads to oxidative stress and chronic inflammation, promoting CVD.

This Special Issue will focus on the mechanisms of redox regulation during CVD development and discuss potential strategies for the re-establishment of redox balance.

Dr. Yiliang Chen
Dr. Jacek Zielonka
Guest Editors

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• oxidative stress
• mitochondria
• metabolism
• chronic inflammation
• atherosclerosis
• CVD
• ROS