The Tumor–Immune Interface for Next-Generation Immunotherapy

Dear Colleagues,

Immunotherapy has revolutionized the treatment of cancers, especially for blood cancers. Nonetheless, the application of immunotherapy in solid tumors is far more challenging. One of the key challenges is the ability of tumors to evade immune surveillance by creating an immunosuppressive microenvironment. Tumor cells can secrete cytokines and chemokines that attract immune-suppressive cells such as regulatory T cells and myeloid-derived suppressor cells, which inhibit anti-tumor immune responses. In addition, tumors can express ligands that interact with immune-checkpoint receptors on T cells, leading to T cell exhaustion and dysfunction. To overcome these challenges, next-generation immunotherapies aim to modulate the tumor–immune interface by either enhancing anti-tumor immune responses or inhibiting immunosuppressive mechanisms. Overall, the tumor–immune interface is a complex and dynamic system that plays a crucial role in tumor progression and response to immunotherapy. Developing next-generation immunotherapies that can effectively modulate the tumor–immune interface is an active area of research and holds promise for improving outcomes for cancer patients. This Special Issue of Cancers therefore encompasses original research articles and comprehensive reviews on all aspects of the tumor–immune interface for next-generation immunotherapy.

Dr. Ziliang Huang
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• immunotherapy
• immunomodulation
• checkpoint blockade
• tumor microenvironment
• CAR
• TCR
• tumor vaccines
• synthetic biology
• biomedical engineering