Four new
p-aminoacetophenonic acids, named (2
E)-11-(4′-aminophenyl)-5,9-dihydroxy-4,6,8-trimethyl-11-oxo-undec-2-enoic acid (
1), 9-(4′-aminophenyl)-3,7-dihydroxy-2,4,6-trimethyl-9-oxo-nonoic acid(
2), (2
E)-11-(4′-aminophenyl)-5,9-
O-cyclo-4,6,8-trimethyl-11-oxo-undec-2-enoic acid (
3) and 9-(4′-aminophenyl)-3,7-
O-cyclo-2,4,6-trimethyl-9-oxo-nonoic acid(
4), were isolated from an endophyte
Streptomyces sp. (strain HK10552) of
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Four new
p-aminoacetophenonic acids, named (2
E)-11-(4′-aminophenyl)-5,9-dihydroxy-4,6,8-trimethyl-11-oxo-undec-2-enoic acid (
1), 9-(4′-aminophenyl)-3,7-dihydroxy-2,4,6-trimethyl-9-oxo-nonoic acid(
2), (2
E)-11-(4′-aminophenyl)-5,9-
O-cyclo-4,6,8-trimethyl-11-oxo-undec-2-enoic acid (
3) and 9-(4′-aminophenyl)-3,7-
O-cyclo-2,4,6-trimethyl-9-oxo-nonoic acid(
4), were isolated from an endophyte
Streptomyces sp. (strain HK10552) of the mangrove plant
Aegiceras corniculatum. The structures of
1–
4 were elucidated by using spectroscopic analyses. The relative stereoconfigurations of compounds
3 and
4 were determined by NOESY experiments. In the bioassay test,
1–
4 showed no cytotoxicity against the Hela cell lines. Compound
4 also showed no inhibitory bioactivity on HCV protease and SecA ATPase and wasn’t active against VSVG/HIV-luc pseudotyping virus.
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