The petroleum ether extract of
Baccharis darwinii showed activity against
Cryptococcus neoformans and dermatophytes. Bioactivity-guided fractionation of
Baccharis darwinii has resulted in the isolation of three coumarins: 5’-hydroxy aurapten (anisocoumarin H,
1), aurapten (7-geranyloxycoumarin,
2) and 5’-oxoaurapten (diversinin,
3). The
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The petroleum ether extract of
Baccharis darwinii showed activity against
Cryptococcus neoformans and dermatophytes. Bioactivity-guided fractionation of
Baccharis darwinii has resulted in the isolation of three coumarins: 5’-hydroxy aurapten (anisocoumarin H,
1), aurapten (7-geranyloxycoumarin,
2) and 5’-oxoaurapten (diversinin,
3). The structures of these compounds were characterized by spectroscopic methods. These compounds were evaluated for their antimicrobialactivity against a panel of each, bacteria and fungi. Compound
3 showed the best activities against
Microsporum gypseum,
Trichophyton rubrum and
Trichophyton mentagrophytes with MICs = 15.6 µg/mL, followed by compound
1 whose MICs against the same fungi were 62.5 µg/mL. In addition they showed fungicidal rather than fungistatic activity
. Both compounds showed moderate activity (MICs = 125 µg/mL) against
Cryptococcus neoformans. This is the first report of the presence of compound
1 in
B. darwinii.
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