Rapid and efficient solvent-free synthesis of 4-amino-3-mercapto-6-[2-(2-thienyl)vinyl]-1,2,4-triazin-5(4
H)-one
1 under microwave irradiation is described. Some new fused heterobicyclic nitrogen systems such as 1,2,4-triazino[3,4-
b][1,3,4]thiadiazinones, 1,3,4-thiadiazolo[2,3-
c][1,2,4]triazinone and pyrazolo[5,1-
c]-[1,2,4]triazine-7-carbonitrile, have been synthesized by treatment of
1 with bifunctional oxygen
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Rapid and efficient solvent-free synthesis of 4-amino-3-mercapto-6-[2-(2-thienyl)vinyl]-1,2,4-triazin-5(4
H)-one
1 under microwave irradiation is described. Some new fused heterobicyclic nitrogen systems such as 1,2,4-triazino[3,4-
b][1,3,4]thiadiazinones, 1,3,4-thiadiazolo[2,3-
c][1,2,4]triazinone and pyrazolo[5,1-
c]-[1,2,4]triazine-7-carbonitrile, have been synthesized by treatment of
1 with bifunctional oxygen and halogen compounds, CS
2/KOH and malononitrile
via heterocyclization reactions, in addition to some uncondensed triazines. Structures of the products have been deduced from their elemental analysis and spectral data (IR,
1H-NMR,
13C-NMR). Select new synthesized compounds were screened as anticancer agents, with some showing activity as cytotoxic agents against different cancer cell lines.
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