The Thirty-Fifth Anniversary of K+ Channels in O2 Sensing: What We Know and What We Don’t Know
Abstract
:1. Physiological Oxygen Sensing: The Carotid Body as an O2 Sensor
2. Oxygen-Sensitive K+ Channels in the Carotid Body
2.1. KV Channels and Oxygen Sensitivity in the Carotid Body
2.2. BKCa Channels and Oxygen Sensitivity in the Carotid Body
2.3. K2P Channels and Oxygen Sensitivity in the Carotid Body
3. What We Know and What We Do Not about the Oxygen Sensors in Chemoreceptor Cells
4. Coupling Mechanisms between the Sensor and the K+ Channels
5. Concluding Remarks on O2 Sensing in the Carotid Body
6. O2-Sensitive K+ Channels in the Pulmonary Vasculature
KV Channels and O2 Sensing in PASMC
7. How Does PO2 Regulate K+ Channels in PASMC?
7.1. Evidence for KV Channel Regulation by Cytoplasmic Redox State
7.2. Evidence for TASK-1 Channel Regulation by Cytoplasmic Redox State
7.3. Other Factors Regulating PASMC K+ Currents during Hypoxia
8. Concluding Remarks: O2 Sensing in CBCC versus PASMCs
Author Contributions
Funding
Conflicts of Interest
References
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Cell Type | Sensor | Mediator | Effector K+ Channel | References |
---|---|---|---|---|
CBCC | Mitochondria/oxidative phosphorylation | ↑ ROS and/or NADH | KV | [50,161] |
↓ ATP | TASK 1/3 | [129] | ||
Thermal transients | TASK 1/3 | [185] | ||
↑ Lactate causes acidification | TASK 1/3(?) | [166] | ||
↑ Lactate activates olfr 78 | ?? | [154] | ||
Heme-oxygenase 2 | ↓ CO binds to heme | BKCa | [86,87] | |
↓ CO causes ↑H2S | BKCa | [100,101,102] | ||
NADPH oxidase | ↓ ROS | ?? | [136] | |
Stress-regulated exon (STREX) causes channel closure via unknown mechanism | BKCa | [90] | ||
O2 interacts directly with channel-associated site to inhibit it via unknown mechanism | KV, BKCa | [47,51,74,133] | ||
PASMC | Mitochondria/oxidative phosphorylation | ↓ ROS | KV1.5 | [33,204,207] |
↑ ROS | KV1.5 | [193,194] | ||
↑ AMP activates AMPK | KV1.5 | [263,264] | ||
?? | ↑ [Ca2+]cyt | KV | [209] | |
?? | Inhibition of src family kinase | TASK 1 | [195,196] | |
?? | ?? | KV7 | [197,219] |
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Rocher, A.; Aaronson, P.I. The Thirty-Fifth Anniversary of K+ Channels in O2 Sensing: What We Know and What We Don’t Know. Oxygen 2024, 4, 53-89. https://doi.org/10.3390/oxygen4010004
Rocher A, Aaronson PI. The Thirty-Fifth Anniversary of K+ Channels in O2 Sensing: What We Know and What We Don’t Know. Oxygen. 2024; 4(1):53-89. https://doi.org/10.3390/oxygen4010004
Chicago/Turabian StyleRocher, Asuncion, and Philip I. Aaronson. 2024. "The Thirty-Fifth Anniversary of K+ Channels in O2 Sensing: What We Know and What We Don’t Know" Oxygen 4, no. 1: 53-89. https://doi.org/10.3390/oxygen4010004