Molecular and Cellular Mechanisms of Megakaryocyte and Platelet Production

Dear Colleagues,

Historically, and from a very broad and general perspective, the study of platelets occurred in the context of thrombosis and hemostasis, while the study of megakaryocytes occurred in the context of oncohematology. However, the acknowledged role of platelets in various physiological processes beyond hemostasis and the demand not only to improve the diagnosis and treatment of platelet disorders but also to understand their contribution to other conditions and to improve platelet-based therapies has triggered the necessity to understand how platelets are produced.

While we have advanced enormously in our understanding of platelet production and function (from megakaryocytes to platelets), we are still at the tip of the iceberg regarding even the generation of tools to study this lineage properly and to understand its role in health and disease in a comprehensive manner. This knowledge will certainly lead to the development of new therapies targeting platelets, platelet-based biomarkers, platelet-based therapeutic bio-products, platelet mimetics, platelet-derived extracellular vesicles, etc.

Given the growing interest in platelets beyond hemostasis and their applications beyond transfusion medicine, we are launching this Special Issue of Biomolecules, where we intend to explore advances in knowledge and present the most up-to-date findings regarding the “Molecular and Cellular Mechanisms of Megakaryocyte and Platelet Production”.

We encourage you and your co-workers to submit articles focused on this research topic. Reviews or original articles are welcome.

We look forward to receiving your contributions to make this initiative a wonderful and complete Special Issue!

Dr. Pedro J. Real
Dr. Laura Gutiérrez
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• megakaryocytes
• platelets
• omics
• platelet disorders
• inflammation