The Application of Pleuroscopy and Bronchoscopy in Lung Cancer
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Methods and Technologies Development".
Deadline for manuscript submissions: 10 February 2025 | Viewed by 63
Special Issue Editor
2. Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Interests: lung cancer; pleural disease; obstructive airway disease; bronchoscopy; pleuroscopy
Special Issue Information
Dear Colleagues,
Since our review paper, entitled “Bronchoscopy in Lung Cancer Appraisal of Current Technology and for the Future”, was published in JTO in 2010, many advancements have been made in terms of techniques and technologies in not only procuring sufficient tissue for molecular characterization and NGS but also the use of these with greater precision to gain access to the CT screened small nodules through robotic bronchoscopy with special tools. In addition, it is possible, in the not-so-distant future, that one-stop diagnosis, staging, and the bronchoscopic treatment of early lung cancer will be possible within the same sitting.
In the realm of palliation, the 3D printing of stents has led to advances in precision medicine, where stents can now be customized to better fit to the airways in order to minimize complications such as obstructing granuloma and migration. Mediastinal EBUS-guided cryobiopsy has also led to an increase in the diagnosis of lymphoma.
Outline
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Advances in Navigating to the Pulmonary Nodule for Biopsy and Ablative Therapy |
With the increased uptake of lung cancer screening worldwide, as well as the increased use of CT coronary angiogram in the assessment of coronary artery disease, a nodule epidemic may be arising, where pulmonologists experience an increase in pressure to biopsy peripheral CT-detected pulmonary nodules. Bronchoscopic techniques have advanced in the last 5 years with the advent of robotic bronchoscopy that allows for access ti be gained beyond 10th generation bronchus for biopsy and cone beam CT, both fixed and mobile or with augmented fluoroscopy/tomosynthesis to confirm the use of particular tools in lesions for biopsy. By negating CT body divergence, staging of the mediastinum with endobronchial ultrasound (EBUS) that demonstrates early-stage lung cancer—stage 1A—would allow for bronchoscopic ablation to occur in the same sitting. |
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Imaging in Peripheral Bronchoscopy |
Advances in peripheral bronchoscopy to target peripheral pulmonary lesions PPL with 1) robotic bronchoscopy and 2) thin bronchoscopy aided by imaging using virtual bronchoscopy/electromagnetic platforms akin to GPS, radial EBUS for the real-time localization of PPL, and tomosynthesis/augmented fluoroscopy to reach the target. |
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What is New in the Staging of the Mediastinum? |
The upcoming ninth edition of IASLC lung cancer staging recommends accessing multistation lymph nodes as they impact prognosis and the radiation field. Improved tools: core needles, forceps, cryoprobe that are inserted into the lymph node/mediastinal mass to obtain tissue particularly useful for benign diseases, e.g., sarcoidosis, lymphoma characterization, and next-generation sequencing in lung cancer |
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Treatment Strategies for Malignant Pulmonary Nodule |
High-level evidence has shown that sublobar resection is as effective as lobectomy for stage IA lung cancer <=2cm. A literature review of ablative therapies using microwave and RFA via the percutaneous or bronchoscopic route will be discussed and how these novel treatments compare with SBRT. |
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Central Airway Obstruction |
Advances in stenting will be highlighted, e.g., 3D- and 4D-printed stents may herald the future of an ideal stent tailored for the patient, incorporating CT and bronch images. |
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Malignant Pleural Effusion: Pleuoscopy and IPC |
Indwelling pleural catheter (IPC) has contributed to keeping the patients at home and providing them with the autonomy for symptom control and palliation. The thoracoscopic pleural cryobiopsy technique has also led to the increased diagnostic rate of malignant mesothelioma, which can be further guided by probe-based confocal laser endomicroscopy to select sites for biopsy. Confocal laser endomicroscopy is a miniaturized probe where the microscope is brought to the pleura for in vivo imaging. |
Prof. Dr. Pyng Lee
Guest Editor
Manuscript Submission Information
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Keywords
- bronchoscopy
- lung cancer
- pleuroscopy
- central airway obstruction
- pulmonary nodule
- stent
- malignant pleural effusion
