Cell–Cell Interactome-Based Therapies for Osteosarcoma
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Microenvironment".
Deadline for manuscript submissions: 30 June 2024 | Viewed by 89
Special Issue Editors
Interests: skeleton growth defects; primary bone tumors; bone microenvironment; pathophysiology
Special Issues, Collections and Topics in MDPI journals
Interests: osteosarcoma; tumor heterogeneity; tumor microenvironment; cell signaling pathway; 3D culture; microfluidics; bone remodeling; drug screening
Special Issue Information
Dear Colleagues,
The therapeutic protocols currently used to treat osteosarcoma are limited in two non-exclusive situations: resistance to chemotherapy agents and the occurrence of metastases. During recent years, researchers have focused their efforts to reduce the occurrence of these situations. For both deleterious events, the qualitative and quantitative composition of cells, as fibroblastic cells (CAF), immune cells (TIL, TAM), endothelial cells and stromal cells, in the tumor microenvironment, as well as the cell–cell interactions have been shown to play a key role. Similarly, the ability of tumor cells to hijack interactions with some of these cells, for example by luring the immune system through the expression of immune checkpoints, is a major factor of poor prognostics, linked to tumor escape.
As such, we are pleased to introduce this Special Issue dedicated to publishing original articles and reviews on all aspects associated to the role of cell–cell interactions in the resistance to treatment and metastatic dissemination of osteosarcoma, which will increase our knowledge in those fields and open therapeutic avenues for the future.
Dr. Frédéric Lézot
Dr. Javier Munoz
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- osteosarcoma
- cell–cell interactions
- microenvironment
- metastases
- resistance
- chemotherapy
- immune checkpoints
