Head and Neck Squamous Cell Carcinomas: Biomarkers and Cellular Mechanisms towards a Precision Therapy

Dear Colleagues,

Head and neck squamous cell carcinoma (HNSCC) is the seventh most prevalent cancer worldwide, characterized by a relatively worse prognosis and the adverse impact of treatments on patients' quality of life. Apart from surgery and radiotherapy, there are only a few available systemic treatments, primarily involving platinum-based chemotherapy or cetuximab. Immunotherapy, a novel therapeutic approach, is currently limited to palliative care for cases of recurrent, unresectable, or metastatic disease. Consequently, the exploration of new biomarkers or potentially targetable mechanisms holds significant importance. The identification of subgroups of patients that could benefit from a de-intensified treatment regimen is also of paramount importance, aimed at a precision therapy reducing the tremendous toxicity of the current treatment modalities for HNSCC.

This Special Issue of Cells is focused on the latest advances and future trends in cellular, molecular, and biomarker research in the field of head and neck cancer. This Special Issue will include both original research articles as well as up-to-date review papers.

Dr. Francesco Missale
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• head and neck cancer
• biomarkers
• prognosis
• precision therapy
• immunotherapy
• translational research
• immune contexture