Exploring the Genetics and Genomics of Complex Diseases

Dear Colleagues,

Complex diseases are caused by a combination of genetics, lifestyle, and environmental risk factors, many of which are still being elucidated. With many complex diseases estimated to have a significant contribution from genetics, the identification of DNA variants of interest from large sequencing efforts and genome-wide association studies have increased our understanding and extended molecular work to biological pathways outside that of initial disease impact. Our understanding of the mechanisms operating at these variants is aided not only by molecular studies but also by the application of bioinformatics and machine-learning approaches to large data sets.

In this special issue of IJMS entitled “Exploring the Genetics and Genomics of Complex Diseases” a broad range of complex diseases and their genetic and genomic aetiology and/or modifiers are explored. It will include a selection of original research articles, current review articles, and communications examining key genetic underpinnings of disease.

Authors of studies from all complex diseases are welcome to contribute, with all areas of genetics, transcriptomics, epigenetics, genomics, and gene-environmental interplay are welcome to contribute.

Dr. Keeley Brookes
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• complex disease
• genetics
• polymorphisms
• genomics
• transcriptome
• epigenetics
• gene-environment interplay