Epigenetic Mechanisms of Cardiac Disease 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 30 June 2024 | Viewed by 179
Special Issue Editor
2. ICMC (Integrated Cardio Metabolic Centre), Myocardial Genetics, Karolinska Institutet, University Hospital, Dept. of Medicine, Heart and Vascular Theme, Novum, Hiss A, Våning 7, Hälsovägen 7-9, 141 57 Huddinge, Sweden
Interests: genetics; heart failure; epigenetics; molecular mechanisms
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Despite major breakthroughs in molecular biology and significant improvements in clinical medicine, heart failure remains a major cause of death worldwide. Our understanding of heart failure remains incomplete, despite that fact that a genetic basis can be identified in 30%–50% of individuals with heart failure and fundamental molecular mechanisms including hypertrophic signaling and a calcium metabolism have been unraveled.
In this context, recent successful clinical trials point to the importance of sophisticated exploitation of already-known signal transduction pathways, inflammation, and the need to explore even more novel biology and take interdisciplinary approaches to improve patients’ lives, for example, through SGLT2 inhibitors and diabeto-cardiology.
Along these lines and apart from genetics, epigenetics (“epi-” means above in Greek)—which is defined as inheritable DNA modifications that do not change the DNA sequence but which can affect gene activity—might play a role. These changes can be direct, for example, via genomic DNA methylations, or indirect, via DNA interacting molecules such as histones or via miRNAs or similar.
In summary, genetic and epigenetic mechanisms are likely to operate in heart failure, the unraveling of which will undoubtedly lead to an improvement in patients’ lives.
In this issue, we will collate a wide variety of papers looking at different aspects of epigenetic mechanisms underlying heart failure.
Dr. Ralph Knoll
Guest Editor
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