Molecular Mechanisms and Pathophysiology of Sepsis

Dear Colleagues,

Considering that antibiosis, eradication of the focus, and intensive care supply are the only treatment regimens for patients suffering from sepsis, it is obvious that new therapies are mandatory. Because the anamneses of sepsis patients are very heterogeneous, characterizing mechanistic details associated with sepsis initiation or progression will help to establish new therapeutic approaches. Therefore, manuscripts elucidating the molecular mechanisms in vitro or in vivo in preclinical models as well as patient studies providing insights into new therapeutic concepts to prevent or treat sepsis progression are welcome. Based on this research topic, this Special Issue aims to collate original research manuscripts and review articles in the field of the origin of sepsis and related therapies.

Submissions of review articles and original research papers that cover topics including, but not limited to, the following are welcome:

1. Cell culture studies characterizing and/or identifying new factors involved in sepsis development.
2. The role of immune cell subpopulations in sepsis progression.
3. Animal models providing mechanistic insights into the underlying principles leading to sepsis.
4. Therapeutic approaches to prevent or cure sepsis and future perspectives.
5. The definition of new sepsis biomarkers.
6. The characterization of putative subgroups of sepsis patients with a similar origin of sepsis.

Dr. Vlad Pădureanu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• animal models
• therapeutic concepts
• biomarkers
• sepsis
• immune suppression
• epigenetics