Hypertension: Mechanisms of Oxidative Stress and Antioxidant Regulation

Dear Colleagues,

Arterial hypertension is known as one of the main chronic diseases, affecting more than 1 billion people worldwide. The complications of this disease include cerebro-vascular stroke, coronary artery disease, heart failure, and kidney disease. These are major causes of morbidity and mortality all around the world. However, arterial blood pressure reduction in hypertensive people can prevent or drastically reduce these complications. Recent studies that were carried out on both humans and animal models showed that the increase in blood pressure is, at least in part, caused by an alteration of the endothelium at the level of the arterioles. This alteration is mainly due to an imbalance between the oxidizing and antioxidant substances normally produced by the body. An increase in oxidant substances, particularly reactive oxygen species (ROS), induces deterrent effects by triggering a cascade of signals that result in endothelial dysfunction that promotes the progression of cardiovascular disorders. Another important aspect is that the increase in pressure determines a geometric rearrangement of the vascular networks, impairing tissue perfusion.

The main aim of this Special Issue is to provide a broad overview of the mechanisms through which oxidative stress causes cardiovascular disorders and analyze the mechanisms underlying the regulatory effects of antioxidative natural substances. We warmly welcome submissions, including original papers and reviews, on this topic of such important public health interest.

Dr. Rossana Scuri
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• arteriolar networks organization
• blood flow supply
• cardiovascular disease
• endothelial dysfunction
• eNOS regulatory activity
• oxidative stress
• polyphenols