Molecular Mechanism in DNA Replication and Repair

Dear Colleagues,

DNA replication, i.e., making a copy of a cell’s DNA, is a process in which approximately 3 billion base pairs of DNA in the genome must be properly copied when any of the cells divide. DNA replication is semiconservative, which means that each strand in the DNA double helix is a template for the synthesis of a complementary strand. Cells copy their DNA in a fast way, and they use multiple enzymes and proteins in this process, including DNA polymerase, DNA primase, DNA helicase, DNA ligase, and topoisomerase. DNA polymerase could make mistakes while adding nucleotides. Most of the mistakes are corrected during replication, but when it is not employed, the mismatch repair mechanism is implemented, which replaces the incorrect bases with the proper ones. Another type of repair is nucleotide excision repair, which removes incorrect bases along with a few bases on the 3′ and 5′ ends and replaces them by copying the template using DNA polymerase. Most of the mistakes are corrected; uncorrected bases result in mutations, which may cause multiple consequences, such as cancer.

This Special Issue of IJMS is dedicated to understanding and expanding the knowledge of molecular and cellular mechanisms of DNA replication and repair. This Special Issue is supervised by Dr. Ryszard Maciejewski and assisted by our Topical Advisory Panel Member, Dr. Julita Machlowska (Medical University of Lublin). We would like to create a platform for multiple research projects and publications on different aspects of DNA replication and repair mechanisms, which might be significant in terms of novel disease therapies.

Prof. Dr. Ryszard Maciejewski
Guest Editor

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• DNA replication
• genome stability
• DNA repair mechanisms
• mismatch repair mechanism
• nucleotide excision repair
• cancer risk