Mitochondrial Biology and Reactive Oxygen Species

Dear Colleagues,

Mitochondria are involved in many processes critical to cell function and dysfunction, including maintaining metabolic and ionic homeostasis, calcium signaling, cell differentiation and growth, cell cycle control and cell death. They are crucial for cellular energy production and the formation of reactive oxygen species (ROS). Mitochondrial coenzyme Q (mtQ) is also involved in mitochondrial reactive oxygen species (mtROS). The redox state of the mtQ pool is a central bioenergetic parameter that alters in response to changes in mitochondrial function. It reflects mitochondrial bioenergetic activity and mtROS formation level and thus the oxidative stress associated with the mitochondria. Under oxidative stress conditions, excessive mtROS production can lead to various oxidative damage, including oxidative modification of cellular macromolecules such as lipids, DNA and proteins, which is the cause of aging and many diseases. In addition, damaged mitochondria release apoptotic factors that act as signals that induce cell death.  In this Special Issue, we aim to gain new and evolving knowledge of mitochondrial biology. We welcome reviews and original research articles encompassing the role of mitochondria in the regulation of metabolic health, mtROS in mitochondrial stress response and metabolic regulation, expand our understanding of the mitochondrial stress response and how it can be leveraged to improve systemic metabolic health.

Dr. Wieslawa Jarmuszkiewicz
Guest Editor

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• mitochondrial biology
• mitochondrial dysfunction
• mitochondrial coenzyme Q
• metabolic homeostasis
• oxidative stress
• reactive oxygen species