Molecular, Translational and Clinical Research of Cancer Structural Biomarkers

Dear Colleagues,

According to the National Cancer Institute, a biomarker is “a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease”, (NCI) such as cancer. Biomarkers are used in cancer research and discovery, translational research and in the clinic to distinguish between healthy individuals vs. cancer patients. Moreover, they are often used to define specific stages of cancer. This issue of IJMS is dedicated to cancer structural biomarkers and follows a theme of previous issues that were focused on cancer biomarkers and informatics and on cancer biomarkers, their mechanisms and potential therapies. Structural biomarkers in cancer are such markers that modulate cellular and nuclear structures which in turn change cellular behaviour. This process is often dynamic and has cancer stage-specific manifestations. Examples of structural biomarkers in cancer may include modulators of extracellular matrix, of nuclear and genome organization, or aberrant DNA, protein, RNA or lipid structures. We are looking for manuscripts that highlight structural cancer biomarker discovery research and/or translational research and/or demonstrate the clinical relevance of the structural biomarkers for cancer patients. Diagnostic, prognostic and treatment relevance are important hallmarks in this field, and studies addressing these topics are welcome.

Prof. Dr. Sabine Mai
Guest Editor

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• structural biomarker
• extracellular matrix
• nuclear organization
• discovery research
• translational research
• clinical research, cancer staging and prognosis
• cancer therapy