Molecular Mechanism and Pathophysiology of Pain

Dear Colleagues,

This Special Issue, entitled "Molecular Mechanisms and Pathophysiology of Pain," delves into the intricate biological processes governing the perception, transmission, and modulation of pain signals within the nervous system. The aim of this Special Issue is to contribute to the clarification of the interplay of various molecular components, including neurotransmitters, receptors, ion channels, and signaling molecules, within the peripheral nerves, spinal cord, and brain regions involved in pain processing. Dysregulation of these molecular mechanisms can lead to chronic pain conditions, including neuropathic pain and inflammatory pain syndromes. Additionally, epigenetic modifications, including DNA methylation and histone modifications, play a crucial role in modulating gene expression and shaping the molecular landscape underlying pain perception. Understanding these mechanisms is essential for developing targeted therapies aimed at alleviating pain and improving the quality of life for individuals affected by acute and chronic pain conditions. By unraveling the complexities of pain biology and identifying novel therapeutic targets, research in this field holds promise for advancing pain management strategies and personalized treatment approaches tailored to the individual patient’s unique molecular profiles. We warmly welcome submissions, including original papers and reviews, focused on (1) novel mechanisms of pain signaling in the peripheral and central nervous systems; (2) mechanisms of chronic pain development; (3) molecular and epigenetic changes involved in pathological pain; (4) novel pain models; and (5) translational studies with therapeutical approaches.

Dr. Stanislava Jergová
Guest Editor

Manuscript Submission Information

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• acute pain mechanism
• chronic pain mechanisms
• pain receptors and neurotransmitter
• epigenetic changes in pain
• pain therapy
• gene therapy in pain
• cell therapy in pain
• pain models