Future Perspectives and Challenges in Brain Tumor

Dear Colleagues,

Brain tumors represent heterogeneous and aggressive diseases, posing significant challenges in terms of complete cure and early-stage prognosis. Despite growing knowledge of the molecular mechanisms underlying their malignancy, rapid progression and relapses, most of them, especially glioblastoma and brain metastases, continue to exhibit unmet medical needs.

New advances in molecular target therapy and immunotherapy, together with the identification of novel prognostic and predictive biomarkers associated with neuroradiological findings, have emerged, but novel paradigms and key targets are urgently needed. This scenario opens the door to new perspectives requiring a multidisciplinary omics approach for personalized medicine and the introduction of new keystones. An emerging field in oncology, as well as for many other human pathologies, is aerospace medicine. The peculiar space environment, characterized, for example, by ionizing radiations, microgravity, oxidative stress, accelerated cellular aging, and hypoxia, may serve as a novel central lever for deeper brain tumor investigations and therapeutic approaches, constituting a study platform not yet explored.

This Special Issue will showcase novel frontiers in neuroncology, i.e., current challenges, potential solutions identified, new practicable roads, and successes achieved and those to which researchers and clinicians aspire. Original research articles, review articles, and short communications within (but not restricted to) the described research fields are welcome.

Dr. Giovanni Marfia
Dr. Laura Guarnaccia
Dr. Stefania Elena Navone
Guest Editors

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• brain tumors
• brain metastases
• therapy resistance
• personalized medicine
• target therapies
• immunotherapy
• aerospace medicine
• microgravity
• cancer stem cells