Epigenetic Modifications in Health and Disease

Dear Colleagues,

Accumulating evidence suggests that epigenetic modifications play a crucial role in chronic disorders such as diabetes mellitus, obesity, and hypertension. Importantly, maternal exposure to different stressors can change the epigenetic landscape of the fetal genome and adversely impact the risk of such disorders in adult life. Among various epigenetic modifications, DNA methylation has emerged as an important regulator of transcription and long-term control of gene expression. Moreover, evidence supports that DNA modification is heritable and alters the health and disease risk for the next few generations.

In this Special Issue of IJMS, we will focus on DNA methylation and its role in metabolic syndrome (hypertension, obesity, and diabetes mellitus). The aim of this Special Issue will be to provide a comprehensive update on the role of DNA methylation in hypertension, obesity, and/or diabetes mellitus. We welcome original research articles and up-to-date review articles.

Dr. Ravi Goyal
Guest Editor

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• proximal promoter methylation
• CpG islands
• Dohad
• fetal programming
• fetal origins of adult disorders
• developmental origins of health and disease