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Molecular Research on Nanotoxicology
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Molecular Research on Nanotoxicology

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: 20 October 2024 | Viewed by 504

Special Issue Editor

Dr. Oleg Lunov

E-Mail Website
Guest Editor
Institute of Physics of the Czech Academy of Sciences, 182 00 Prague, Czech Republic
Interests: nanotoxicology; cell biophysics; cell mechanics; molecular biology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Despite decades of extensive research, the development of novel nanomaterials is still in progress, opening new avenues for biomedical applications. The potential adverse reactions and toxicity of the growing number of novel nanomaterials applied in various biomedical fields introduce concerns. In order to ameliorate the potential adverse reactions of nanomaterials and increase their successful translation to real-world applications, it is crucial to understand the basic molecular mechanisms that drive toxic and adverse reactions.

Therefore, this Special Issue is dedicated to papers from all over the world that deal with nanotoxicology and/or the adverse reactions of nanomaterials utilized in healthcare.

Dr. Oleg Lunov
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanotoxicology
  • nanodrugs
  • nanoparticles
  • adverse drug reactions
  • cytotoxicity

Published Papers (1 paper)

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Research

17 pages, 3627 KiB  
Article
Encapsulation of Nanoparticles with Statistical Copolymers with Different Surface Charges and Analysis of Their Interactions with Proteins and Cells
by Saad Megahed, Nicole Wutke, Yang Liu, Markus Klapper, Florian Schulz, Neus Feliu and Wolfgang J. Parak
Int. J. Mol. Sci. 2024, 25(10), 5539; https://doi.org/10.3390/ijms25105539 - 19 May 2024
Viewed by 335
Abstract
Encapsulation with polymers is a well-known strategy to stabilize and functionalize nanomaterials and tune their physicochemical properties. Amphiphilic copolymers are promising in this context, but their structural diversity and complexity also make understanding and predicting their behavior challenging. This is particularly the case [...] Read more.
Encapsulation with polymers is a well-known strategy to stabilize and functionalize nanomaterials and tune their physicochemical properties. Amphiphilic copolymers are promising in this context, but their structural diversity and complexity also make understanding and predicting their behavior challenging. This is particularly the case in complex media which are relevant for intended applications in medicine and nanobiotechnology. Here, we studied the encapsulation of gold nanoparticles and quantum dots with amphiphilic copolymers differing in their charge and molecular structure. Protein adsorption to the nanoconjugates was studied with fluorescence correlation spectroscopy, and their surface activity was studied with dynamic interfacial tensiometry. Encapsulation of the nanoparticles without affecting their characteristic properties was possible with all tested polymers and provided good stabilization. However, the interaction with proteins and cells significantly depended on structural details. We identified statistical copolymers providing strongly reduced protein adsorption and low unspecific cellular uptake. Interestingly, different zwitterionic amphiphilic copolymers showed substantial differences in their resulting bio-repulsive properties. Among the polymers tested herein, statistical copolymers with sulfobetaine and phosphatidylcholine sidechains performed better than copolymers with carboxylic acid- and dimethylamino-terminated sidechains. Full article
(This article belongs to the Special Issue Molecular Research on Nanotoxicology)
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