Prevention of Atherosclerosis and of Low-Density Lipoprotein Oxidation: Role of Dietary Antioxidant Compounds and Altered Redox Pathways. A Commemorative Special Issue in Honour of Professor Stanley Omaye
A special issue of Antioxidants (ISSN 2076-3921).
Deadline for manuscript submissions: 30 August 2024 | Viewed by 3762
Special Issue Editors
Interests: polyphenol antioxidants of dietary origin; conjugates of polyphenols with sulphydryl compounds of biological relevance; antioxidants from marine sources; valorization of agri food wastes; synthesis and exploitation of biopolymers from natural polyphenols; chemistry and structural investigation of natural polymers from catechols including human epidermal pigments melanins; oxidation chemistry of catecholamines in relation to neurodegenerative disorders; design and preparation of polydopamine related biomaterials with peculiar adhesive properties
Special Issues, Collections and Topics in MDPI journals
Interests: eryptosis; antioxidants; oxidative stress; signaling patterns; inflammation; brain metabolism
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The incidence of cardiovascular disease (CVD) increases markedly with age and is the largest contributor to morbidity and premature mortality in men and women. Increased levels of low-density lipoprotein (LDL) and free-radical-mediated oxidative damage of LDL represent a key risk factor and a key step in the pathogenesis of atherosclerosis. Indeed, oxidised LDL (oxLDL) plays a crucial role in the development of a chronic, low-grade inflammation state that strongly supports the evolution of CVD. Other mechanisms, including altered redox signalling and antioxidant pathways, may also be involved in the onset and development of these pathological conditions.
Approaches aimed at attenuating the risk of CVD, and which are based on dietary or supplemental antioxidants, have been increasingly investigated regarding the ability of different antioxidants and their combinations to protect LDL from oxidation. Other valuable strategies involve the targeting of altered redox signalling and the expression of antioxidant enzymes.
The research work developed by Professor Omaye and his collaborators has focused on nutraceuticals and their mode of action, particularly on antioxidant vitamins including ascorbate, alpha-tocopherol, and beta-carotene as protective agents against atherosclerosis and CVD. These vitamins have been shown to protect LDL against oxidative modification both in ex vivo supplementation studies and in vitro loading studies, suggesting that the protective effects against atherosclerosis associated with their intake may be mediated by their antioxidative activities.
This Special Issue dedicated to Professor Stanley Omaye will honour his memory, providing the latest insights into the actual role of antioxidants of dietary origin in the prevention of CVD, emerging from in vitro, animal studies and human trials. Altered redox mechanisms involved in CVD onset also represent a relevant and central topic of interest.
Original research papers, reviews and case studies addressing the topics reported below are herein welcome:
- Studies aiming to investigate the mechanisms underlying the protective effects of antioxidants against oxLDL-related CVD;
- Investigations into the ability of dietary antioxidants to counteract oxLDL-induced low-grade inflammation in CVD;
- Epidemiological studies on the protective effects of dietary antioxidants against oxLDL-related CVD;
- Studies on the bioavailability of dietary antioxidants;
- Methodologies to investigate the action of antioxidants in experimental systems simulating LDL oxidation;
- Investigations on redox signalling and altered antioxidant pathways related to CVD onset.
Prof. Dr. Alessandra Napolitano
Dr. Mario Allegra
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- LDL
- oxidative stress
- antioxidants
- chronic, low-grade inflammation
- vitamins
- antioxidant enzymes
- redox signalling
