Amyotrophic Lateral Sclerosis: the Search for Markers of Presymptomatic Disease
A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neuromuscular and Movement Disorders".
Deadline for manuscript submissions: closed (25 October 2021) | Viewed by 272
Special Issue Editors
Interests: ALS; motor cortex; corticomotoneuronal system; preclinical
Special Issues, Collections and Topics in MDPI journals
Interests: ALS clinical trials; patient care and management; ALS biomarkers; ALS epidemiology; multidisciplinary ALS clinic; ALS end-of-life issues; ALS education; ALS guidelines; ALS international collaboration; primary lateral sclerosis (PLS)
Special Issue Information
Dear Colleagues,
Despite several decades of intensive research into amyotrophic lateral sclerosis (ALS), the cause and meaningful therapy remain enigmatic. To date, favourable responses to treatments in animal models have not been translated to those in the human disease. There are many reasons for this failure, but the most important may be the lengthy preclinical, followed by a long presymptomatic, period for ALS. This likely lasts for several years, if not decades. In the preclinical and presymptomatic periods, sick, dysfunctional and dying neurons can be rescued, preventing progression to symptomatic ALS. This dream can only be realized by the development of disease markers capable of detecting ALS during the preclinical years. This Special Issue is devoted to discussing makers of ALS that are showing promise in the early detection of the disorder.
Prof. Dr. Andrew Eisen
Prof. Dr. Hiroshi Mitsumoto
Guest Editors
Manuscript Submission Information
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Keywords
- amyotrophic lateral sclerosis
- pre-clinical
- presymptomatic
- markers of early ALS
