Histone Variants
A special issue of Epigenomes (ISSN 2075-4655).
Deadline for manuscript submissions: 30 September 2024 | Viewed by 727
Special Issue Editor
Special Issue Information
Dear Colleagues,
Histone proteins wrap around DNA, forming nucleosomes that serve to package and organize DNA within the nucleus while controlling its accessibility.
In addition to the canonical histones, there are variant histones that possess distinct gene and mRNA structures, as well as unique amino acid sequences compared with their canonical counterparts. Unlike canonical histones, which are primarily expressed during the S phase and deposited onto chromatin through a replication-coupled mechanism, histone variants are expressed throughout the cell cycle and deposited at specific genomic locations via a replication-independent process, facilitated by variant-specific histone chaperones.
Replacing canonical histones with variant histones within a nucleosome imparts unique properties to the nucleosomes, influencing chromatin stability, dynamics, and organization. Histone variants have been shown to play pivotal roles in processes such as transcription, DNA replication and repair, chromosome segregation, and those related to development, aging, and diseases like cancer.
This Special Issue is focused on the latest advances in our understanding of various aspects related to histone variants. We welcome submissions of reviews, research articles, and method manuscripts that offer exceptional insights into the following topics:
- Histone variants, their chaperones, and deposition mechanisms.
- Post-translational modifications of histone variants.
- Histone variants in regulating nucleosome stability, structure, and function.
- Histone variants in genome integrity and epigenetic memory.
- Alterations in histone variants in response to environmental exposures.
- Histone variants in development, aging, and disease.
Dr. Chunyuan Jin
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Epigenomes is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- histone variant
- epigenetics
- chaperone
- chromatin
- nucleosome
- assembly
- post-translational modification
- gene expression
- replication-independent
