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Histoplasma and Histoplasmosis, 4th Edition
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Histoplasma and Histoplasmosis, 4th Edition

A special issue of Journal of Fungi (ISSN 2309-608X). This special issue belongs to the section "Fungal Pathogenesis and Disease Control".

Deadline for manuscript submissions: 15 June 2024 | Viewed by 168

Special Issue Editors

Prof. Dr. Mathieu Nacher

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Guest Editor
Medicine Department, Ecosystemes Amazoniens et Pathologie Tropicale, EA 3593, Labex CEBA, University of French Guiana, Cayenne, France
Interests: HIV infectious diseases; malaria; AIDS; Plasmodium; Falciparum malaria; Vivax malaria
Special Issues, Collections and Topics in MDPI journals
Dr. Antoine A. Adenis

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Guest Editor
Centre d’Investigation Clinique Antilles Guyane, CIC INSERM 1424, Centre Hospitalier de Cayenne, 97300 Cayenne, France
Interests: fungal infections; tropical medicine; epidemiology; public health; HIV
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Progressive disseminated histoplasmosis is still too often underdiagnosed; this has resulted in a great burden of avoidable deaths in Latin America and presumably in other continents. There are diagnostic difficulties for this proteiform disease that lead to a significant risk of death; these diagnostic problems also lead to a lack of data and awareness among physicians. Despite recent WHO/PAHO histoplasmosis diagnosis and treatment guidelines, challenges still lay ahead, especially in low- and middle-income countries. There are still many unanswered questions regarding the natural history of disseminated histoplasmosis and who should be tested, when, and what to do if the test is positive in patients without symptoms. The disease burden beyond the Americas, reports documenting the scaling-up of diagnoses and treatments, prognostic factors, new tools and strategies, and the disease’s rising incidence in non-HIV immunosuppression are examples of topics that this Special Issue of the Journal of Fungi will seek to explore.

Prof. Dr. Mathieu Nacher
Dr. Antoine A. Adenis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Fungi is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • histoplasma
  • histoplasmosis
  • endemic fungi
  • opportunistic infections
  • AIDS
  • fungal epidemiology

Published Papers (1 paper)

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Research

12 pages, 1019 KiB  
Article
Histoplasmosis in Non-HIV Infected Patients: Another Neglected Infection in French Guiana
by Houari Aissaoui, Morgane Bourne-Watrin, Benoit Lemarie, Genevieve Guillot, Alolia Aboikoni, Piseth Chhorn, Dana Gaudard, Ghazi Hadj-Amara, Ricardo Manasse, Mahamado Ouedraogo, Charles Salloum, Magalie Demar, Loïc Epelboin, Hatem Kallel, Antoine Adenis, Mathieu Nacher, Kinan Drak Alsibai and Dominique Louvel
J. Fungi 2024, 10(6), 400; https://doi.org/10.3390/jof10060400 (registering DOI) - 1 Jun 2024
Abstract
(1) Background: Only a few studies on histoplasmosis in immunocompetent patients have been reported in French Guiana. Therefore, we conducted a detailed clinical description of hospitalized patients suffering with histoplasmosis among non-HIV patients. (2) Methods: This is a single-center, retrospective study conducted at [...] Read more.
(1) Background: Only a few studies on histoplasmosis in immunocompetent patients have been reported in French Guiana. Therefore, we conducted a detailed clinical description of hospitalized patients suffering with histoplasmosis among non-HIV patients. (2) Methods: This is a single-center, retrospective study conducted at Cayenne Hospital Center between 2008 and 2022. (3) Results: Our cohort was composed of 31 (91%) adults (>18 years of age) and 3 (9%) children, with a sex ratio, M:F, of 1:2. The median age was higher among the women than among the men (70 versus 54 years). The collection of respiratory samples constituted the majority of the performed examinations (38%). Fever (>37 °C) was found in 56% of patients. Surprisingly, the histoplasmosis was disseminated in 82% of patients with an overall case fatality rate of 14.7%. However, immunosuppressive conditions were found in 52% (16/31) of the adult patients, including lymphoid hemopathies, diabetes and immunosuppressive drugs. Conclusions: This disease, though rare and usually considered a mostly benign disease in non-HIV patients, presented a relatively high mortality rate in our cohort. Thus, histoplasmosis should be suspected, screened and investigated as a first line of defense in highly endemic areas, even in immunocompetent and non-HIV patients, especially those with fever or chronic respiratory symptoms. Full article
(This article belongs to the Special Issue Histoplasma and Histoplasmosis, 4th Edition)
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