Pericytes Are Immunoregulatory Cells in Glioma Genesis and Progression
Abstract
:1. Introduction
2. The Role of Pericytes in Glioblastoma Multiforme Generation and Progression
3. Cellular Immunity in Glioblastoma Multiforme
3.1. Cells in Glioma TME
3.1.1. Tumor Cells
3.1.2. Immune Cells
- Pericytes
- 2.
- Tumor-Associated Macrophages (TAMs)
- 3.
- M2-like Microglia
3.2. Origin of Cells in Glioma TME
4. Therapeutic Challenges
Immunotherapy
- Immune Checkpoint Inhibitors: These drugs target proteins that inhibit the immune response, such as PD-1 or CTLA-4. By blocking these proteins, immune cells can recognize and attack cancer cells more effectively.
- Therapeutic vaccines are designed to train the immune system to recognize specific antigens found on glioma cells. These vaccines stimulate an immune response against the tumor.
- Chimeric Antigen Receptor (CAR) T Cell Therapy: This involves modifying a patient’s own T cells to recognize specific antigens on glioma cells. The modified T cells are then reintroduced into the patient to target and destroy the tumor cells.
- Tumor-Infiltrating Lymphocytes (TILs): TIL therapy involves extracting immune cells from the tumor, selecting the ones that recognize the tumor, multiplying them in the lab, and infusing them back into the patient.
- Cytokine Therapy: This involves using cytokines, which are small proteins involved in cell signaling, to stimulate the immune system to attack cancer cells.
5. Strategies for Targeting GBM–Pericyte Interactions
Author Contributions
Funding
Conflicts of Interest
References
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Martinez-Morga, M.; Garrigos, D.; Rodriguez-Montero, E.; Pombero, A.; Garcia-Lopez, R.; Martinez, S. Pericytes Are Immunoregulatory Cells in Glioma Genesis and Progression. Int. J. Mol. Sci. 2024, 25, 5072. https://doi.org/10.3390/ijms25105072
Martinez-Morga M, Garrigos D, Rodriguez-Montero E, Pombero A, Garcia-Lopez R, Martinez S. Pericytes Are Immunoregulatory Cells in Glioma Genesis and Progression. International Journal of Molecular Sciences. 2024; 25(10):5072. https://doi.org/10.3390/ijms25105072
Chicago/Turabian StyleMartinez-Morga, Marta, Daniel Garrigos, Elena Rodriguez-Montero, Ana Pombero, Raquel Garcia-Lopez, and Salvador Martinez. 2024. "Pericytes Are Immunoregulatory Cells in Glioma Genesis and Progression" International Journal of Molecular Sciences 25, no. 10: 5072. https://doi.org/10.3390/ijms25105072