Exposure to Microcystin-LR Promotes Colorectal Cancer Progression by Altering Gut Microbiota and Associated Metabolites in APCmin/+ Mice
Abstract
:1. Introduction
2. Results
2.1. MC-LR Promoted the Colorectal Tumor Progression and Impaired Intestinal Barrier Function in APCmin/+ Mice
2.2. MC-LR Exposure Did Not Induce Changes in the Alpha Diversity of the Intestinal Microbial Community
2.3. Exposure to MC-LR Altered the Structure of the Gut Microbiota
2.4. MC-LR Exposure Aggravated Microbial-Induced Dysregulation of BA Metabolism
3. Discussion
4. Conclusions
5. Materials and Methods
5.1. Animals and Experimental Design
5.2. Sample and Data Collection
5.3. Histopathological Examination
5.4. Full-Length 16S Sequencing and Data Processing
5.5. Biodiversity Analysis
5.6. Metabolomic Profiling and Data Analysis
5.7. Statistical Analysis
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Song, Y.; Wang, X.; Lu, X.; Wang, T. Exposure to Microcystin-LR Promotes Colorectal Cancer Progression by Altering Gut Microbiota and Associated Metabolites in APCmin/+ Mice. Toxins 2024, 16, 212. https://doi.org/10.3390/toxins16050212
Song Y, Wang X, Lu X, Wang T. Exposure to Microcystin-LR Promotes Colorectal Cancer Progression by Altering Gut Microbiota and Associated Metabolites in APCmin/+ Mice. Toxins. 2024; 16(5):212. https://doi.org/10.3390/toxins16050212
Chicago/Turabian StyleSong, Yuechi, Xiaochang Wang, Xiaohui Lu, and Ting Wang. 2024. "Exposure to Microcystin-LR Promotes Colorectal Cancer Progression by Altering Gut Microbiota and Associated Metabolites in APCmin/+ Mice" Toxins 16, no. 5: 212. https://doi.org/10.3390/toxins16050212