Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
8.8
7.0
Journals
Antioxidants
Special Issues
Reactive Oxygen Species (ROS) in Gastrointestinal Diseases—2nd Edition
share announcement

Reactive Oxygen Species (ROS) in Gastrointestinal Diseases—2nd Edition

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (15 April 2024) | Viewed by 3182

Special Issue Editors

Prof. Dr. Young Do Jung

E-Mail Website
Guest Editor
Department of Biochemistry, Chonnam National University Medical School, Hwasun 58128, Republic of Korea
Interests: cancer; signaling; transcription factor; gene regulation; ROS; antioxidants
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Yong Xia

E-Mail Website
Guest Editor
Institute of Precision Medicine, Jining Medical University, Jining 272067, China
Interests: oxidative stress; gene regulation; molecular oncology; tumor microenvironment; pharmacological mechanism
Dr. Sen Lian

E-Mail Website
Guest Editor
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China
Interests: anticancer target; molecular mechanism; cell signaling pathway; gastrointestinal cancer
Special Issues, Collections and Topics in MDPI journals
Dr. Shinan Li

E-Mail Website
Guest Editor
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, China
Interests: molecular oncology; ROS; transcription factor; gene regulation; tumor microenvironment
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Reactive oxygen species (ROS) play a crucial role in developing various chronic and degenerative gastrointestinal diseases, such as cancer and digestive system disorders. ROS, including superoxide and hydrogen peroxide, can act as secondary messengers in intracellular signaling pathways during cancer cell progression and are associated with multiple signaling cascades that modulate cell proliferation, invasion, and angiogenesis.

For this Special Issue, we invite researchers to submit original research articles and review articles covering, but not limited to, the following topics:

  • Novel antioxidant molecules with a wide range of applications, including large molecular antioxidant compounds, such as polymers and macromolecular compounds. In particular, this includes their applications in clinical medicines, natural compounds, synthesized compounds, and other bioactive chemicals for gastrointestinal diseases.
  • Mechanisms underlying the action of antioxidant molecules, providing a foundation for developing new antioxidant drugs.
  • The role of ROS in the development of gastrointestinal diseases.

We welcome contributions from a wide range of fields, including medicinal chemistry, biochemistry, molecular oncology, nutrition, molecular biology, and more.

We look forward to receiving your contributions to this Special Issue.

Prof. Dr. Young Do Jung
Prof. Dr. Yong Xia
Dr. Sen Lian
Dr. Shinan Li
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • reactive oxygen species (ROS)
  • gastrointestinal diseases
  • antioxidant molecules
  • intracellular signaling
  • cancer cell progression

Published Papers (4 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

13 pages, 670 KiB  
Article
Effects of Crude Extract of Glycyrrhiza Radix and Atractylodes macrocephala on Immune and Antioxidant Capacity of SPF White Leghorn Chickens in an Oxidative Stress Model
by Chaosheng Zhang, Shaolong Wang, Yunsheng Han, Aijuan Zheng, Guohua Liu, Kun Meng, Peilong Yang and Zhimin Chen
Antioxidants 2024, 13(5), 578; https://doi.org/10.3390/antiox13050578 - 8 May 2024
Viewed by 381
Abstract
The natural edible characteristics of Chinese herbs have led more and more people to study them as an alternative product to antibiotics. In this study, crude extracts of Glycyrrhiza radix and Atractylodes macrocephala (abbreviated as GRAM) with glycyrrhizic acid content not less than [...] Read more.
The natural edible characteristics of Chinese herbs have led more and more people to study them as an alternative product to antibiotics. In this study, crude extracts of Glycyrrhiza radix and Atractylodes macrocephala (abbreviated as GRAM) with glycyrrhizic acid content not less than 0.2 mg/g were selected to evaluate the effects of GRAM on the immune and antioxidant capacity of model animals. Thirty 21-day-old male Leghorn chickens were weighed and randomly assigned to one of three groups of ten animals each. The treatments comprised a control group (CON), in which saline was injected at day 31, day 33, and day 35, an LPS-treated group (LPS), in which LPS (0.5 mg/kg of BW) was injected at day 31, day 33, and day 35, and finally a GRAM and LPS-treated group, (G-L) in which a GRAM-treated diet (at GRAM 2 g/kg) was fed from day 21 to day 35 with LPS injection (0.5 mg/kg of BW) at day 31, day 33, and day 35. The results of diarrhea grade and serum antioxidant measurement showed that the LPS group had obvious diarrhea symptoms, serum ROS and MDA were significantly increased, and T-AOC was significantly decreased. The oxidative stress model of LPS was successfully established. The results of immune and antioxidant indexes showed that feeding GRAM significantly decreased levels of the pro-inflammatory factors TNF-α, IL-1β, and IL-6 (p < 0.05) and significantly increased levels of the anti-inflammatory factors IL-4 and IL-10 and levels of the antioxidant enzymes GSH-Px and CAT (p < 0.05). GRAM resisted the influence of LPS on ileum morphology, liver, and immune organs and maintained normal index values for ileum morphology, liver, and immune organs. In summary, this study confirmed the antidiarrheal effect of GRAM, which improved the immune and antioxidant capacity of model animals by regulating inflammatory cytokine levels and antioxidant enzyme activity in poultry. Full article
(This article belongs to the Special Issue Reactive Oxygen Species (ROS) in Gastrointestinal Diseases—2nd Edition)
►▼ Show Figures

Figure 1

20 pages, 5969 KiB  
Article
Ziziphus jujuba Miller Ethanol Extract Restores Disrupted Intestinal Barrier Function via Tight Junction Recovery and Reduces Inflammation
by Ye Jin Yang, Min Jung Kim, Ho Jeong Lee, Won-Yung Lee, Ju-Hye Yang, Hun Hwan Kim, Min Sup Shim, Ji Woong Heo, Jae Dong Son, Woo H. Kim, Gon Sup Kim, Hu-Jang Lee, Young-Woo Kim, Kwang Youn Kim and Kwang Il Park
Antioxidants 2024, 13(5), 575; https://doi.org/10.3390/antiox13050575 - 7 May 2024
Viewed by 516
Abstract
Inflammatory bowel disease (IBD) is a chronic inflammatory condition caused by the disruption of the intestinal barrier. The intestinal barrier is maintained by tight junctions (TJs), which sustain intestinal homeostasis and prevent pathogens from entering the microbiome and mucosal tissues. Ziziphus jujuba Miller [...] Read more.
Inflammatory bowel disease (IBD) is a chronic inflammatory condition caused by the disruption of the intestinal barrier. The intestinal barrier is maintained by tight junctions (TJs), which sustain intestinal homeostasis and prevent pathogens from entering the microbiome and mucosal tissues. Ziziphus jujuba Miller (Z. jujuba) is a natural substance that has been used in traditional medicine as a therapy for a variety of diseases. However, in IBD, the efficacy of Z. jujuba is unknown. Therefore, we evaluated ZJB in Caco2 cells and a dextran sodium sulfate (DSS)-induced mouse model to demonstrate its efficacy in IBD. Z. jujuba extracts were prepared using 70% ethanol and were named ZJB. ZJB was found to be non-cytotoxic and to have excellent antioxidant effects. We confirmed its anti-inflammatory properties via the down-regulation of inflammatory factors, including inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). To evaluate the effects of ZJB on intestinal barrier function and TJ improvement, the trans-epithelial electrical resistance (TEER) and fluorescein isothiocyanate-dextran 4 kDa (FITC-Dextran 4) permeability were assessed. The TEER value increased by 61.389% and permeability decreased by 27.348% in the 200 μg/mL ZJB group compared with the 50 ng/mL IL-6 group after 24 h. Additionally, ZJB alleviated body weight loss, reduced the disease activity index (DAI) score, and induced colon shortening in 5% DSS-induced mice; inflammatory cytokines, tumor necrosis factor (TNF)-α, and interleukin (IL)-6 were down-regulated in the serum. TJ proteins, such as Zonula occludens (ZO)-1 and occludin, were up-regulated by ZJB in an impaired Caco2 mouse model. Additionally, according to the liquid chromatography results, in tandem with mass spectrometry (LC-MS/MS) analysis, seven active ingredients were detected in ZJB. In conclusion, ZJB down-regulated inflammatory factors, protected intestinal barrier function, and increased TJ proteins. It is thus a safe, natural substance with the potential to be used as a therapeutic agent in IBD treatment. Full article
(This article belongs to the Special Issue Reactive Oxygen Species (ROS) in Gastrointestinal Diseases—2nd Edition)
►▼ Show Figures

Figure 1

21 pages, 4543 KiB  
Article
Sulforaphane Inhibits IL-1β-Induced IL-6 by Suppressing ROS Production, AP-1, and STAT3 in Colorectal Cancer HT-29 Cells
by Dhiraj Kumar Sah, Archana Arjunan, Seon Young Park, Bora Lee and Young Do Jung
Antioxidants 2024, 13(4), 406; https://doi.org/10.3390/antiox13040406 - 28 Mar 2024
Viewed by 907
Abstract
Colorectal cancer (CRC) stands as a major cause of cancer-related mortality globally, accounting for approximately 881,000 deaths each year. Traditional approaches such as chemotherapy and surgery have been the primary treatment modalities, yet the outcomes for patients with metastatic CRC are often unsatisfactory. [...] Read more.
Colorectal cancer (CRC) stands as a major cause of cancer-related mortality globally, accounting for approximately 881,000 deaths each year. Traditional approaches such as chemotherapy and surgery have been the primary treatment modalities, yet the outcomes for patients with metastatic CRC are often unsatisfactory. Recent research has focused on targeting the pathways involved in oxidative stress, inflammation, and metastasis to enhance the survival of CRC patients. Within this context, sulforaphane (SFN), a notable phytochemical found predominantly in cruciferous vegetables, has been recognized as a potential anticancer agent. However, the specific mechanisms through which SFN may exert its chemopreventive effects in CRC remain unclear. This study explores the impact of SFN on IL-1β-induced IL-6 activation and MAPK and AP-1 signaling in HT-29 cells. Our findings reveal that SFN treatment not only diminishes IL-1β-stimulated IL-6 expression but also reduces oxidative stress by curtailing reactive oxygen species (ROS) production. Furthermore, it hinders the proliferation and invasiveness of HT-29 cells through the modulation of MAPK/AP-1 and STAT3 signaling pathways. These results indicate that SFN mitigates IL-1β-induced IL-6 expression in CRC cells by attenuating ROS production and disrupting MAPK/AP-1 signaling. This suggests that SFN holds significant potential as a chemotherapeutic agent for both treating and preventing CRC. Full article
(This article belongs to the Special Issue Reactive Oxygen Species (ROS) in Gastrointestinal Diseases—2nd Edition)
►▼ Show Figures

Figure 1

18 pages, 4483 KiB  
Article
Potential Phytotherapy of DSS-Induced Colitis: Ameliorating Reactive Oxygen Species-Mediated Necroptosis and Gut Dysbiosis with a New Crataegus pinnatifida Bunge Variety—Daehong
by Kang-In Lee, Yousang Jo, Heung Joo Yuk, Sun-Young Kim, Hyungjun Kim, Hye Jin Kim, Soo-Keol Hwang and Ki-Sun Park
Antioxidants 2024, 13(3), 340; https://doi.org/10.3390/antiox13030340 - 12 Mar 2024
Viewed by 968
Abstract
Developing new plant varieties plays a crucial role in competitiveness in the agricultural and food industries and enhancing food security. Daehong (DH) is a new variety of Crataegus pinnatifida Bunge (CP); however, its physiological functions and potential as a nutraceutical ingredient remain unknown. [...] Read more.
Developing new plant varieties plays a crucial role in competitiveness in the agricultural and food industries and enhancing food security. Daehong (DH) is a new variety of Crataegus pinnatifida Bunge (CP); however, its physiological functions and potential as a nutraceutical ingredient remain unknown. Here, the efficacy of DH on inflammatory bowel disease (IBD) was investigated using dextran sulfate sodium (DSS)-induced colitis mice, and its relative pharmacological effects were analyzed against CP. DH improved colitis-induced weight loss, colon shortening, and inflammatory responses and reduced intestinal permeability. The reactive oxygen species (ROS)-mediated necroptotic signal that triggers enterocyte cell death in DSS-induced colitis was effectively controlled by DH, attributed to epicatechin. DSS-induced gut dysbiosis was recovered into a healthy gut microbiome environment by DH, increasing beneficial bacteria, like Akkermansia muciniphila, and changing harmful bacteria, including Bacteroides vulgatus and Peptostreptococcaceae. DH shows potential as a dietary or pharmaceutical ingredient to promote gut health and to prevent and treat IBD. Full article
(This article belongs to the Special Issue Reactive Oxygen Species (ROS) in Gastrointestinal Diseases—2nd Edition)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-4
Back to TopTop