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Dear colleagues,

The emergence of epithermal neutron sources in hospitals has made boron neutron capture therapy (BNCT) a focus of innovative developments in radiation oncology.

Given the rapid progress in clinical and preclinical research on BNCT, we invite contributions for this Special Issue of Cells in the form of original research articles and reviews on all cellular aspects related to BNCT.

Relevant topics include, but are not limited to, the following:

Radiation biology for BNCT;
Cell-based studies;
Drug development for BNCT;
Impact of BNCT on the proteomic profile and omics approaches;
Boron imaging;
Mechanisms of action of BNCT;
Immunological aspects, including abscopal effect of BNCT;
Biomarkers for therapeutic optimization.

Prof. Dr. Wolfgang Sauerwein
Prof. Dr. Mitsuko Masutani
Prof. Dr. Lucie Sancey
Prof. Dr. John Hopewell
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Published Papers (1 paper)

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15 pages, 515 KiB

Open AccessProtocol

Early Stage In Vitro Bioprofiling of Potential Low-Molecular-Weight Organoboron Compounds for Boron Neutron Capture Therapy (BNCT)—Proposal for a Guide

by Zbigniew J. Leśnikowski, Filip Ekholm, Narayan S. Hosmane, Martin Kellert, Eiji Matsuura, Hiroyuki Nakamura, Agnieszka B. Olejniczak, Luigi Panza, Louis M. Rendina and Wolfgang A. G. Sauerwein

Cells 2024, 13(10), 798; https://doi.org/10.3390/cells13100798 - 8 May 2024

Viewed by 678

Abstract

Given the renewed interest in boron neutron capture therapy (BNCT) and the intensified search for improved boron carriers, as well as the difficulties of coherently comparing the carriers described so far, it seems necessary to define a basic set of assays and standardized methods to be used in the early stages of boron carrier development in vitro. The selection of assays and corresponding methods is based on the practical experience of the authors and is certainly not exhaustive, but open to discussion. The proposed tests/characteristics: Solubility, lipophilicity, stability, cytotoxicity, and cellular uptake apply to both low molecular weight (up to 500 Da) and high molecular weight (5000 Da and more) boron carriers. However, the specific methods have been selected primarily for low molecular weight boron carriers; in the case of high molecular weight compounds, some of the methods may need to be adapted. Full article

(This article belongs to the Special Issue Cell Biology for Boron Neutron Capture Therapy (BNCT))

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