Recent Advances in Pediatric-Onset Multiple Sclerosis
A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Child Neurology".
Deadline for manuscript submissions: 5 July 2024 | Viewed by 580
Special Issue Editors
Interests: neuroinflammation; pediatric onset multiple sclerosis; myelitis; pediatric neurology
Special Issue Information
Dear Colleagues,
In 2–5% of patients with multiple sclerosis, the first clinical symptoms manifest before the age of 18. Although patients with pediatric-onset multiple sclerosis (POMS) have a longer interval until they reach irreversible disability, this occurs at a younger age than in patients with adult-onset disease. In addition, patients with pediatric-onset multiple sclerosis show a higher inflammatory activity with a 2-3-fold increased frequency of relapses compared to patients with adult-onset multiple sclerosis. In contrast to the widely used hesitant treatment approach with the start of injectable therapies and step-wise escalation, recent studies suggest that applying newer disease-modifying therapies (DMTs) as initial treatment improves disease control. A wide range of DMTs are available for adult use; however, in the pediatric population, only three DMTs (fingolimod, teriflunomide, and dimethyl fumarate) are currently approved for treatment. Observational studies suggest similar effects and side effects in pediatric and adult-onset cohorts; therefore, off-label use of other DMTs is widely applied.
This Special Issue aims to gather scientific evidence relating to new advances in POMS with special focus on new treatment regimens, advances in diagnostic tools, neuropsychological aspects, and follow-up.
We welcome all researchers to take part in this effort and share their experience and novel and ongoing research through this Special Issue.
Dr. Markus Breu
Dr. Christian Lechner
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- multiple sclerosis
- pediatric
- POMS
- inflammation
- demyelination
- pediatric neurology
