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Diagnostics
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Pediatric Gastrointestinal Pathology
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Pediatric Gastrointestinal Pathology

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 669

Special Issue Editor

Dr. Juan Putra

E-Mail Website
Guest Editor
Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA
Interests: pediatric pathology; liver pathology; vascular anomalies; gastrointestinal pathology

Special Issue Information

Dear Colleagues,

Special considerations are required for the evaluation of gastrointestinal pathology in the pediatric population. The spectrum of pediatric gastrointestinal tract disorders is broad, and the diagnosis often requires a different approach from that in adults. In addition, certain conditions (e.g., congenital enteropathies, monogenic inflammatory bowel disease) are rarely encountered, even at large pediatric centers. Thus, these specimens pose unique diagnostic challenges for many practicing pathologists. The aim of this Special Issue is to highlight recent advances in the field of pediatric gastrointestinal pathology. This Special Issue will also provide a practical overview of relevant disorders for pathologists and clinicians who diagnose and manage pediatric patients. Various types of articles (e.g., case series, original research, reviews) on common and rare entities are welcome.

Dr. Juan Putra
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • inflammatory bowel disease
  • crohn disease
  • celiac disease
  • ulcerative colitis
  • vascular anomalies
  • eosinophilic esophagitis

Published Papers (1 paper)

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Research

12 pages, 2866 KiB  
Article
Pediatric Crohn’s Disease in the Upper Gastrointestinal Tract: Clinical, Laboratory, Endoscopic, and Histopathological Analysis
by Dunja Putniković, Jovan Jevtić, Nina Ristić, Ivan D. Milovanovich, Miloš Đuknić, Milica Radusinović, Nevena Popovac, Irena Đorđić, Zoran Leković and Radmila Janković
Diagnostics 2024, 14(9), 877; https://doi.org/10.3390/diagnostics14090877 - 24 Apr 2024
Viewed by 540
Abstract
Crohn’s disease (CD) is a progressive, multifactorial, immune-mediated disease characterized by chronic inflammation of any part of the gastrointestinal (GI) tract. Pediatric patients present with a more extensive form of the disease, especially in the upper GI tract with various histopathological inflammatory patterns. [...] Read more.
Crohn’s disease (CD) is a progressive, multifactorial, immune-mediated disease characterized by chronic inflammation of any part of the gastrointestinal (GI) tract. Pediatric patients present with a more extensive form of the disease, especially in the upper GI tract with various histopathological inflammatory patterns. Our study aims to analyze the clinical, laboratory, endoscopic, and histopathological findings in children with diagnosed CD and compare results on the initial and follow-up tests. We have included 100 children and adolescents with CD, with performed endoscopic and histopathological (HP) procedures. The results of multiple biopsies executed in these 8 years were matched and compared. We found a statistically significant frequency reduction in stool changes (65.52% to 18.18%), weight loss (35.24% to 4%), and abdominal pain (41.86% to 6.67%) as presenting symptoms. There was an improvement in all laboratory values: fecal calprotectin (1000 to 60,8 μg/g), C-reactive protein (12.2 to 1.9 mg/L), and albumin (36 to 41 g/L). On esophagogastroduodenoscopy and ileo-colonoscopy 36.59% and 64.86% patients had specific findings, respectively. A total of 32 patients had evidence of Crohn’s disease in the upper GI tract. Non-caseating granulomas were found on 9% of oesophageal, 18% of gastric, and 12% of duodenal biopsies. In the lower GI tract, we have observed a disease progression in the rectum (72.29 to 82.22%) and descending colon (73.49 to 80%). There was no registered disease progression in the upper GI tract. Our study demonstrated a significant decline in the frequency of symptoms and an improvement in laboratory values on the follow-up examinations. More than a third of our patients had specific endoscopic and HP findings in the upper GI tract, and an additional 23% had HP findings highly suggestive of CD. We demonstrated the importance of regular clinical, laboratory, endoscopic, and histopathological assessments of pediatric CD patients. Full article
(This article belongs to the Special Issue Pediatric Gastrointestinal Pathology)
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