Cardiovascular Disease: Precision Medicine, Pharmacogenomics and Genetics

Dear Colleagues,

Cardiovascular disease (CVD) is the leading cause of death worldwide, accounting for ~32% of global deaths. Genetic contributions, traditional risk factors (e.g., hyperlipidemia and hypertension), behaviors (e.g., smoking and nutrition) and their comorbidities are incompletely understood. In clinical practice, considerable interindividual variability in the response to cardiovascular pharmacotherapy, such as statins, ACEIs, and β-blockers, induces severe adverse events. Broad clinical and genetic heterogeneity in the CVD risk and therapeutic efficacy highlights the urgent need for precision phenotyping. Precision medicine integrates clinical and health record datasets with advanced panomics (i.e., genomics, transcriptomics, epigenomics, metabolomics, and microbiomics) to uncover vascular disease phenotypes and select the corresponding pharmacotherapeutics based on the framework of interactome networks. Personalized medicine offers the potential to optimize the benefit–risk profile of cardiovascular drugs by tailoring the diagnostic and treatment strategies according to individual patients with CVD.

The purpose of this Special Issue is to host research and review papers on the modification of genetic variability in the response to cardiovascular drugs and their potential molecular mechanisms. New results, confirmatory results, and contradictory results will also be considered for publication.

Prof. Dr. Shanqun Jiang
Guest Editor

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• cardiovascular disease (CVD)
• precision medicine
• epigenomics