Molecular Advances in Gut Microbiota and Its Interaction with Immune System

Dear Colleagues,

The composition of the gut microbiome plays an important role in the overall health of the host, including the maintenance of immunological homeostasis. Numerous studies have revealed that powerful molecular interactions between various taxa of the gut microbiome and its counteractive host immune system components take place. The purpose of this Special Issue is to facilitate the presentation of such findings with emphasis on the formulation of novel hypotheses that might lead to interventional therapies and/or treatments.

As the research from the past two decades indicates, critical areas include, but are not limited to:

• Gut dysbiosis vs. chronic intestinal/systemic inflammation.
• Diet-induced gut dysbiosis vs. pathogenesis of mucosa-associated/systemic disease.
• Gut microbiome and cancer.
• Gut dysbiosis vs. autoimmunity (Inflammatory Bowel Disease, Celiac Disease, etc.).
• Gut dysbiosis vs. development of neuropathological disorders.
• Identification of gut microbiota-derived immunomodulatory metabolites including their impact on intestinal epithelium, i.e., gut permeability.
• Elucidation of novel host epithelial cell derived micro RNAs and their interactions with specific species of host gut microbiome.
• Identification of new therapeutical interventions capable of modulating and reversing gut dysbiosis.

In summary, in this Special Issue, we welcome original research articles, as well as review/opinion articles with a focus on molecular interactions between the gut microbiome and host immune system.

Dr. Karol Sestak
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• gut microbiota
• dysbiosis
• gut permeability
• intestinal inflammation
• autoimmunity
• IBD