International Journal of Molecular Sciences

Journal Browser

► Journal Browser

Special Issue Editor

Dr. Rosemary Kiernan

E-Mail Website
Guest Editor

Gene Regulation Laboratory, Institut de Génétique Humaine, UMR 9002, CNRS, Université de Montpellier, 141, rue de la Cardonille, 34396 Montpellier, France
Interests: transcription; ncRNAs; miRNAs; HIV; cancer

Special Issue Information

Dear Colleagues,

RNA Biology: Unraveling the Complex Interplay between Proteins and RNAs in Gene Expression and Regulation delves into the intricate dance between proteins and RNAs in the complex world of gene expression and regulation. This Special Issue will explore the latest advancements in our collective understanding of the diverse roles of RNAs, from their transcriptional genesis to their post-transcriptional modifications, in shaping cellular function. We highlight the complexity of interactions between RNAs and proteins, including RNA-binding proteins, which orchestrate gene expression patterns and cellular responses. Furthermore, we encourage cutting-edge research on the emerging role of non-coding RNAs in gene regulation, epigenetic modifications, and disease pathogenesis. Through these studies, we can gain better insight into the dynamic and multifaceted nature of RNA biology, paving the way for future therapeutic interventions and biotechnological applications.

Dr. Rosemary Kiernan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

RNA biology
protein–RNA interplay
gene expression
post-transcriptional modifications
non-coding RNAs

Published Papers (1 paper)

Research

19 pages, 11576 KiB

Open AccessArticle

miR-107 Targets NSG1 to Regulate Hypopharyngeal Squamous Cell Carcinoma Progression through ERK Pathway

by Yifan Hu, Zhizhen He, Baoai Han, Zehua Lin, Peng Zhou, Shuang Li, Shuo Huang and Xiong Chen

Int. J. Mol. Sci. 2024, 25(11), 5961; https://doi.org/10.3390/ijms25115961 - 29 May 2024

Viewed by 162

Abstract

Hypopharyngeal squamous cell carcinoma (HSCC) is a kind of malignant tumor with a poor prognosis and low quality of life in the otolaryngology department. It has been found that microRNA (miRNA) plays an important role in the occurrence and development of various tumors. This study found that the expression level of miRNA-107 (miR-107) in HSCC was significantly reduced. Subsequently, we screened out the downstream direct target gene Neuronal Vesicle Trafficking Associated 1 (NSG1) related to miR-107 through bioinformatics analysis and found that the expression of NSG1 was increased in HSCC tissues. Following the overexpression of miR-107 in HSCC cells, it was observed that miR-107 directly suppressed NSG1 expression, leading to increased apoptosis, decreased proliferation, and reduced invasion capabilities of HSCC cells. Subsequent experiments involving the overexpression and knockdown of NSG1 in HSCC cells demonstrated that elevated NSG1 levels enhanced cell proliferation, migration, and invasion, while the opposite effect was observed upon NSG1 knockdown. Further investigations revealed that changes in NSG1 levels in the HSCC cells were accompanied by alterations in ERK signaling pathway proteins, suggesting a potential regulatory role of NSG1 in HSCC cell proliferation, migration, and invasion through the ERK pathway. These findings highlight the significance of miR-107 and NSG1 in hypopharyngeal cancer metastasis, offering promising targets for therapeutic interventions and prognostic evaluations for HSCC. Full article

(This article belongs to the Special Issue RNA Biology: Unraveling the Complex Interplay between Proteins and RNAs in Gene Expression and Regulation)

► Show Figures

Figure 1

Journal Menu

Journal Browser

RNA Biology: Unraveling the Complex Interplay between Proteins and RNAs in Gene Expression and Regulation

Share This Special Issue

Special Issue Editor

Special Issue Information

Keywords

Published Papers (1 paper)

Research

Further Information

Guidelines

MDPI Initiatives

Follow MDPI