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Clinical Management of Children and Adolescents with Asthma
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Clinical Management of Children and Adolescents with Asthma

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Pediatrics".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 173

Special Issue Editors

Prof. Dr. Michele Miraglia del Giudice

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Guest Editor
Department of Woman, Child and General and Specialized Surgery, University of Campania 'Luigi Vanvitelli', Naples, Italy
Interests: allergy; pediatrics; respiratory diseases; asthma; atopy; atopic dermatitis; allergic rhinitis; food allergy; biological drugs; immunotherapy; prevention
Special Issues, Collections and Topics in MDPI journals
Dr. Giorgio Ciprandi

E-Mail Website
Co-Guest Editor
Allergy Clinic, Department of Outpatients, Casa di Cura Villa Montallegro, Genoa, Italy
Interests: allergy; asthma; respiratory infections; immunology; inflammation
Special Issues, Collections and Topics in MDPI journals
Dr. Maria Angela Tosca

E-Mail Website
Co-Guest Editor
Allergy Center, Department of Pediatrics, Istituto Giannina Gaslini, Genoa, Italy
Interests: pediatrics; allergy; asthma; immunology; infections
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Asthma is a chronic condition that affects the airways, resulting in the inflammation and narrowing of air passages. The symptoms of asthma can be mild to severe, and can have a significant impact on a child's quality of life. Children and adolescents with asthma represent a significant and growing population of patients requiring clinical care.

The management of asthma in children and adolescents requires ongoing research and evidence-based practices to improve the quality of care and outcomes for this population. The development of new treatments and interventions, as well as the optimization of existing therapies, is essential for the effective management of asthma in children and adolescents.

This Special Issue, Clinical Management of Children and Adolescents with Asthma, focuses on the latest research and clinical practices related to the diagnosis, treatment, and management of asthma in children and adolescents. It covers a wide range of topics, from the pathophysiology of asthma to the use of pharmacological and non-pharmacological interventions, discussing the current challenges and future prospects of managing asthma in children and adolescents.

Prof. Dr. Michele Miraglia del Giudice
Dr. Giorgio Ciprandi
Dr. Maria Angela Tosca
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • asthma
  • children
  • adolescents
  • diagnosis
  • treatment
  • management
  • pharmacological interventions
  • non-pharmacological interventions

Published Papers (1 paper)

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Review

13 pages, 666 KiB  
Review
Exploring the Interplay between Asthma and Hemoglobinopathies: A Comprehensive Review
by Cristiana Indolfi, Giulio Dinardo, Carolina Grella, Angela Klain, Alessandra Perrotta, Gianluca Mondillo, Maria Maddalena Marrapodi, Fabio Decimo and Michele Miraglia del Giudice
J. Clin. Med. 2024, 13(11), 3263; https://doi.org/10.3390/jcm13113263 - 31 May 2024
Abstract
Asthma, a prevalent chronic respiratory condition characterized by inflammation of the airways and bronchoconstriction, has demonstrated a potential association with hemoglobinopathies such as thalassemia and sickle cell disease (SCD). Numerous studies have highlighted a higher prevalence of asthma among thalassemia patients compared to [...] Read more.
Asthma, a prevalent chronic respiratory condition characterized by inflammation of the airways and bronchoconstriction, has demonstrated a potential association with hemoglobinopathies such as thalassemia and sickle cell disease (SCD). Numerous studies have highlighted a higher prevalence of asthma among thalassemia patients compared to the general population, with rates ranging around 30%. Similarly, asthma frequently coexists with SCD, affecting approximately 20–48% of patients. Children with SCD often experience heightened lower airway obstruction and airway hyper-reactivity. Notably, the presence of asthma in SCD exacerbates respiratory symptoms and increases the risk of severe complications like acute chest syndrome, stroke, vaso-occlusive episodes, and early mortality. Several studies have noted a decrease in various cytokines such as IFN-γ and IL-10, along with higher levels of both IL-6 and IL-8, suggesting an overactivation of pro-inflammatory mechanisms in patients with hemoglobinopathies, which could trigger inflammatory conditions such as asthma. The exact mechanisms driving this association are better elucidated but may involve factors such as chronic inflammation, oxidative stress, and immune dysregulation associated with thalassemia-related complications like chronic hemolytic anemia and iron overload. This review aims to comprehensively analyze the relationship between asthma and hemoglobinopathies, with a focus on thalassemia and SCD. It emphasizes the importance of interdisciplinary collaboration among pulmonologists, hematologists, and other healthcare professionals to effectively manage this complex interplay. Understanding this link is crucial for improving care and outcomes in affected individuals. Full article
(This article belongs to the Special Issue Clinical Management of Children and Adolescents with Asthma)
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