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Women’s Special Issue Series: Medicine
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Women’s Special Issue Series: Medicine

A special issue of Medicina (ISSN 1648-9144).

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 8726

Special Issue Editors

Dr. Caroline A. Abbott

E-Mail Website
Guest Editor
Department of Life Sciences, Manchester Metropolitan University, Manchester, UK
Interests: diabetes and its complications; the diabetic foot; peripheral neuropathy; peripheral vascular disease; lower limb amputation; ethnicity; smart healthcare technologies
Prof. Dr. Diana Žaliaduonytė

E-Mail Website
Guest Editor
Lithuanian University of Health Sciences Kaunas Hospital, Kaunas, Lithuania
Interests: ischemic heart disease; heart failure; left ventricular remodeling; valvular heart diseases; echocardiography; cardioimaging
Dr. Marta Dyszkiewicz-Konwińska

E-Mail Website
Guest Editor
Department of Diagnostics, Poznan University of Medical, 61-701 Poznan, Poland
Interests: dentistry; oral mucosa; oral derived stem cells and exosomes; biomaterials; maxillo-facial radiology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to announce a new Special Issue for Medicina—“Women’s Special Issue Series: Medicine”—to celebrate and highlight the international achievements of female researchers in the fields of medicine and clinical science.

For this Special Issue, we are seeking the submission of original research articles and comprehensive review papers from, but not limited to, cardiology, cardiovascular and clinical diabetes, dental and oral health and women’s health, plus any other medicine-related subjects. The papers in this Special Issue will be published via our open access platform after a thorough peer review.

The purpose of our Special Issue is to promote and celebrate the latest achievements of women in medicine and clinical science. While we encourage contributions where the lead/senior author is female, we welcome submissions from all authors, irrespective of their gender identity. We look forward to receiving your excellent work.

Dr. Caroline A. Abbott
Prof. Dr. Diana Žaliaduonytė
Dr. Marta Dyszkiewicz-Konwińska
Guest Editors

Women’s Special Issue Series

This Special Issue is part of Medicina's Women's Special Issue Series, hosted by women editors for women researchers. The Series advocates the advancement of women in science. We invite contributions to the Special Issue whose lead authors identify as women. The submission of articles with all-women authorship is especially encouraged. However, we do welcome articles from all authors, irrespective of gender.

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiology
  • cardiovascular and clinical diabetes
  • complications of the lower limb, and smart technologies
  • ischemic heart disease
  • heart failure
  • valvular heart diseases
  • echocardiography
  • dentistry
  • oral health
  • regenerative dentistry
  • maxillofacial imaging and diagnostics

Published Papers (4 papers)

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Research

11 pages, 324 KiB  
Article
Woman-Centered Care: Standardized Outcomes Measure
by Milda Nagineviciute, Egle Bartuseviciene and Aurelija Blazeviciene
Medicina 2023, 59(9), 1537; https://doi.org/10.3390/medicina59091537 - 25 Aug 2023
Viewed by 1564
Abstract
Background and Objectives: Patient- or woman-centered care, prioritizing women’s perspectives, needs, and preferences, is a widely recommended approach to enhance the quality of maternity care services. It aligns with the broader principles of patient-centered care, emphasizing the importance of a collaborative and [...] Read more.
Background and Objectives: Patient- or woman-centered care, prioritizing women’s perspectives, needs, and preferences, is a widely recommended approach to enhance the quality of maternity care services. It aligns with the broader principles of patient-centered care, emphasizing the importance of a collaborative and respectful relationship between healthcare providers and women. This study evaluates low-risk pregnancies managed by midwives and obstetrician-gynecologists in Lithuania using patient-reported outcome measures and patient-reported experience measures. Materials and Methods: A prospective cohort study was conducted between September 2022 and April 2023. Data were collected through patient-reported questionnaires. Results: A total of 153 pregnant women who had singleton, low-risk pregnancies participated in the study, of whom 24.8% had their pregnancies supervised by a midwife, and 75.2% of the participants had their pregnancies supervised by an obstetrician-gynecologist. The study found no statistically significant differences in assessed patient-reported outcome measures and patient-reported experience measures between both models of care. Conclusions: Adopting patient-centered approaches enables healthcare systems to understand and address women’s specific needs and preferences, fostering high-quality and woman-centered care. This research adds to the growing evidence supporting midwife-led care and emphasizes the importance of personalized, woman-centered approaches in maternity care, ultimately enhancing maternal health outcomes and promoting positive experiences for low-risk pregnant women. The quality of care provided by midwives remains uncompromised and equivalently proficient compared to the care provided by collaborative teams. Full article
(This article belongs to the Special Issue Women’s Special Issue Series: Medicine)
11 pages, 727 KiB  
Article
A Randomized, Multicenter, Double-Blind, Parallel, Non-Inferiority Clinical Study to Compare the Efficacy and Safety of Unicenta and Melsmon for Menopausal Symptom Improvement
by Seongmin Kim, Sanghoon Lee, Ki-Hoon Ahn, Hyun-Tae Park, Jae-Yun Song, Soon-Cheol Hong and Tak Kim
Medicina 2023, 59(8), 1382; https://doi.org/10.3390/medicina59081382 - 28 Jul 2023
Cited by 1 | Viewed by 1237
Abstract
This study was conducted to evaluate the efficacy and safety of Unicenta in female subjects with menopausal symptoms by analyzing the changes in the Kupperman index (primary endpoint) and hormonal changes (secondary endpoint). It was a randomized, multi-center, double-blind, parallel, non-inferiority clinical study [...] Read more.
This study was conducted to evaluate the efficacy and safety of Unicenta in female subjects with menopausal symptoms by analyzing the changes in the Kupperman index (primary endpoint) and hormonal changes (secondary endpoint). It was a randomized, multi-center, double-blind, parallel, non-inferiority clinical study conducted at two different tertiary medical centers. A Unicenta injection was shown to be non-inferior to Melsmon based on the Kupperman index in both the intent-to-treat and per-protocol populations (p = 0.789 and p = 0.826, respectively). Additionally, there were no statistically significant differences in hormone levels (estradiol, follicular-stimulating hormone) or in the evaluation of facial flushes. There was no statistically significant difference in the incidence rate of adverse events between the two groups (p = 0.505). The study demonstrated that Unicenta is not inferior to Melsmon in terms of the change in the Kupperman index after 12 days of injection. The efficacy and safety of Unicenta were shown, resulting in the improvement of menopausal symptoms. Full article
(This article belongs to the Special Issue Women’s Special Issue Series: Medicine)
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9 pages, 878 KiB  
Article
Diagnostic Test Accuracy of Artificial Intelligence in Detecting Periapical Periodontitis on Two-Dimensional Radiographs: A Retrospective Study and Literature Review
by Julien Issa, Mouna Jaber, Ismail Rifai, Paul Mozdziak, Bartosz Kempisty and Marta Dyszkiewicz-Konwińska
Medicina 2023, 59(4), 768; https://doi.org/10.3390/medicina59040768 - 15 Apr 2023
Cited by 5 | Viewed by 3151
Abstract
This study aims to evaluate the diagnostic accuracy of artificial intelligence in detecting apical pathosis on periapical radiographs. A total of twenty anonymized periapical radiographs were retrieved from the database of Poznan University of Medical Sciences. These radiographs displayed a sequence of 60 [...] Read more.
This study aims to evaluate the diagnostic accuracy of artificial intelligence in detecting apical pathosis on periapical radiographs. A total of twenty anonymized periapical radiographs were retrieved from the database of Poznan University of Medical Sciences. These radiographs displayed a sequence of 60 visible teeth. The evaluation of the radiographs was conducted using two methods (manual and automatic), and the results obtained from each technique were afterward compared. For the ground-truth method, one oral and maxillofacial radiology expert with more than ten years of experience and one trainee in oral and maxillofacial radiology evaluated the radiographs by classifying teeth as healthy and unhealthy. A tooth was considered unhealthy when periapical periodontitis related to this tooth had been detected on the radiograph. At the same time, a tooth was classified as healthy when no periapical radiolucency was detected on the periapical radiographs. Then, the same radiographs were evaluated by artificial intelligence, Diagnocat (Diagnocat Ltd., San Francisco, CA, USA). Diagnocat (Diagnocat Ltd., San Francisco, CA, USA) correctly identified periapical lesions on periapical radiographs with a sensitivity of 92.30% and identified healthy teeth with a specificity of 97.87%. The recorded accuracy and F1 score were 96.66% and 0.92, respectively. The artificial intelligence algorithm misdiagnosed one unhealthy tooth (false negative) and over-diagnosed one healthy tooth (false positive) compared to the ground-truth results. Diagnocat (Diagnocat Ltd., San Francisco, CA, USA) showed an optimum accuracy for detecting periapical periodontitis on periapical radiographs. However, more research is needed to assess the diagnostic accuracy of artificial intelligence-based algorithms in dentistry. Full article
(This article belongs to the Special Issue Women’s Special Issue Series: Medicine)
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13 pages, 3700 KiB  
Article
Circulating CD4+ Treg, CD8+ Treg, and CD3+ γδ T Cell Subpopulations in Ovarian Cancer
by Rong Li, Juan Xu, Ming Wu, Shuna Liu, Xin Fu, Wenwen Shang, Ting Wang, Xuemei Jia and Fang Wang
Medicina 2023, 59(2), 205; https://doi.org/10.3390/medicina59020205 - 20 Jan 2023
Cited by 3 | Viewed by 2018
Abstract
Background and Objectives: Regulatory T cells (Tregs) are usually enriched in ovarian cancer (OC), and their immunosuppressive function plays a key role in tumorigenesis and progression. We mainly explored the phenotypical characterization of Treg-related markers on αβ and γδ T cell subsets [...] Read more.
Background and Objectives: Regulatory T cells (Tregs) are usually enriched in ovarian cancer (OC), and their immunosuppressive function plays a key role in tumorigenesis and progression. We mainly explored the phenotypical characterization of Treg-related markers on αβ and γδ T cell subsets in patients with OC. Materials and Methods: Thirty-six untreated patients with OC at the Women’s Hospital of Nanjing Medical University from September 2019 to August 2021 were enrolled. Phenotypical characterization of Tregs-related markers were detected by flow cytometry (FCM). Enzyme-linked immunosorbent assay was used to detect the levels of carbohydrate antigen (CA125) and transforming growth factor β (TGF-β). The level of human epididymis protein 4 (HE4) was detected by electrochemiluminescence immunoassay. Results: Circulating CD4+ Tregs, CD8+ Tregs, and CD3+γδ T cell subpopulations from OC patients have elevated Foxp3, CD25, CD122, Vδ1, and reduced CD28 expression compared to benign ovarian tumor (BOT) patients and healthy controls (HC). The upregulation of Foxp3 and Vδ1 and the downregulation of CD28 were highly specific for maintaining the immunosuppression function of CD4+ Tregs, CD3+γδ T cells, and CD8+ Tregs in OC patients. These Treg subpopulations were able to discriminate OC from BOT and HC. The levels of CA125, HE4, and TGF-β were increased in OC patients. A significant positive correlation between Treg subpopulations and CA125, HE4, and TGF-β was revealed. Conclusions: Proportions of CD4+ Tregs, CD8+ Tregs, and CD3+γδ T cell subsets were significantly increased in OC patients and were positively correlated with FIGO stage/metastasis status, CA125, HE4, and TGF-β. These indicators have the potential to be used as immunosurveillance biomarkers for OC. Full article
(This article belongs to the Special Issue Women’s Special Issue Series: Medicine)
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