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13 pages, 1543 KiB

Open AccessArticle

Effect of Mechanical Surface Treatment on Shear Bond Strength of Orthodontic Brackets to 3D Printed and Milled CAD/CAM Provisional Materials: An In Vitro Study

by Abdulaziz A. Alzaid, Khalid K. Alanazi, Lulu A. Alyahya, Maha N. Alharbi, Hatem Alqarni, Mohammed Alsaloum, Hayam A. Alfallaj and Ghada S. Alotaibi

J. Funct. Biomater. 2024, 15(12), 358; https://doi.org/10.3390/jfb15120358 - 25 Nov 2024

Abstract

The aim of the study is to assess the impact of mechanical surface treatments on the shear bond strength (SBS) of orthodontic brackets bonded to three-dimensional (3D) printed and milled CAD/CAM provisional materials. Sixty cylindrical samples were fabricated for each provisional material. Samples [...] Read more.

The aim of the study is to assess the impact of mechanical surface treatments on the shear bond strength (SBS) of orthodontic brackets bonded to three-dimensional (3D) printed and milled CAD/CAM provisional materials. Sixty cylindrical samples were fabricated for each provisional material. Samples were treated with one of the following surface treatments: aluminum oxide airborne particle abrasion, diamond bur rotary instrument roughening, and phosphoric acid etching (control). Stainless steel brackets were bonded to the samples, and then SBS was tested using a universal testing machine. SEM and digital microscopy were utilized to examine the bonding interface and the failure modes. Two-way ANOVA, one-way ANOVA, Tukey’s HSD, and independent sample t-tests were used for statistical analysis. Results revealed significant differences in SBS between 3D printed and milled samples and significant differences in SBS among most surface treatments, with rotary instrument roughening resulting in the highest values for 3D printed, while airborne particle abrasion leading for milled samples. Digital microscopy indicated that more adhesive remained on 3D-printed samples. SEM analysis revealed varying surface roughness across treatments. Based on the findings of this study, it can be concluded that different surface treatments improve the bonding of orthodontic brackets to provisional crowns. Full article

(This article belongs to the Special Issue Biomechanical Studies and Biomaterials in Dentistry)

20 pages, 3605 KiB

Open AccessArticle

Climate Change Effects on Land Use and Land Cover Suitability in the Southern Brazilian Semiarid Region

by Lucas Augusto Pereira da Silva, Edson Eyji Sano, Taya Cristo Parreiras, Édson Luis Bolfe, Mário Marcos Espírito-Santo, Roberto Filgueiras, Cristiano Marcelo Pereira de Souza, Claudionor Ribeiro da Silva and Marcos Esdras Leite

Land 2024, 13(12), 2008; https://doi.org/10.3390/land13122008 (registering DOI) - 25 Nov 2024

Abstract

Climate change is expected to alter the environmental suitability of land use and land cover (LULC) classes globally. In this study, we investigated the potential impacts of climate change on the environmental suitability of the most representative LULC classes in the southern Brazilian [...] Read more.

Climate change is expected to alter the environmental suitability of land use and land cover (LULC) classes globally. In this study, we investigated the potential impacts of climate change on the environmental suitability of the most representative LULC classes in the southern Brazilian semiarid region. We employed the Random Forest algorithm trained with climatic, soil, and topographic data to project future LULC suitability under the Representative Concentration Pathway RCP 2.6 (optimistic) and 8.5 (pessimistic) scenarios. The climate data included the mean annual air temperature and precipitation from the WorldClim2 platform for historical (1970–2000) and future (2061–2080) scenarios. Soil data were obtained from the SoilGrids 2.1 digital soil mapping platform, while topographic data were produced by NASA’s Shuttle Radar Topography Mission (SRTM). Our model achieved an overall accuracy of 60%. Under the worst-case scenario (RCP 8.5), croplands may lose approximately 8% of their suitable area, while pastures are expected to expand by up to 30%. Areas suitable for savannas are expected to increase under both RCP scenarios, potentially expanding into lands historically occupied by forests, grasslands, and eucalyptus plantations. These projected changes may lead to biodiversity loss and socioeconomic disruptions in the study area. Full article

(This article belongs to the Special Issue Global Savanna Variation in Form and Function: Theory & Practice)

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34 pages, 3125 KiB

Open AccessArticle

Material Flow Analysis: An Analytical Tool for Strategic Planning Towards a Zero-Waste Solution for End-of-Life Ballast Flows on a Track and Ballast Renewal Site (French Conventional Line)

by Olivier Giboulot, Emmanuel Lemelin, Christophe Binetruy and Nor-Edine Abriak

Resources 2024, 13(12), 165; https://doi.org/10.3390/resources13120165 (registering DOI) - 25 Nov 2024

Abstract

The 27,000 km of railway track in France represents approximately 100 million tonnes of ballast. This ballast requires maintenance approximately every 7 years, screening and partial renewal every 20 years, and complete replacement every 40 years. Despite its shortcomings, ballast is still widely [...] Read more.

The 27,000 km of railway track in France represents approximately 100 million tonnes of ballast. This ballast requires maintenance approximately every 7 years, screening and partial renewal every 20 years, and complete replacement every 40 years. Despite its shortcomings, ballast is still widely used on railways worldwide, as there is no better or more efficient solution currently available. In an effort to conserve resources, companies such as SNCF (French national railway company) are implementing initiatives to move towards zero waste. In order to achieve the goal of promoting the recycling and recovery of end-of-life material flows, it is necessary to develop specific studies and models for production, such as direct and reverse logistics systems. This article proposes a generic material flow analysis model applied to a track and ballast renewal site, aiming to fill a gap in the literature. It is based on data from eleven track and ballast renewal sites. A flow diagram generated by STAN software presents a detailed diagnosis of ballast inputs, outputs, and stocks, including data uncertainty. The distribution of the material flows through the model is characterized by transfer coefficients in various transformation processes. Furthermore, by varying the quantities in this model, it is possible to study different scenarios based on the current situation. This will facilitate the projection and analysis of future management strategies aimed at achieving zero waste and reducing the discharge of toxic substances based on specific performance indicators. Full article

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17 pages, 3585 KiB

Open AccessArticle

Immunological Responses, Expression of Immune-Related Genes, and Disease Resistance of Rainbow Trout (Oncorhynchus mykiss) Fed Diets Supplied with Capsicum (Capsicum annuum) Oleoresin

by Sevdan Yilmaz, Osman Nezih Kenanoğlu, Sebahattin Ergün, Ekrem Şanver Çelik, Mert Gürkan, Elsayed Eldeeb Mehana and Hany M. R. Abdel-Latif

Animals 2024, 14(23), 3402; https://doi.org/10.3390/ani14233402 (registering DOI) - 25 Nov 2024

Abstract

A 45-day feeding study was carried out to assess the immune-stimulatory effects of capsicum oleoresin when added to rainbow trout diets. A total of 450 fish (mean weight: 155.20 ± 1.96 g) were distributed into 400 L tanks (30 fish/tank) across five experimental [...] Read more.

A 45-day feeding study was carried out to assess the immune-stimulatory effects of capsicum oleoresin when added to rainbow trout diets. A total of 450 fish (mean weight: 155.20 ± 1.96 g) were distributed into 400 L tanks (30 fish/tank) across five experimental groups: control (CT, 0%), C7 (0.7%), C14 (1.4%), C21 (2.1%), and C28 (2.8%). Each group consisted of three replicate tanks. At the end of this period, hemato-biochemical parameters, innate immune responses, and immune-related gene expression levels were evaluated, and a histological examination of head kidney and liver sections was conducted. Finally, fish in all groups were challenged with Lactococcus garvieae and observed for an additional 20 days. The results revealed that oleoresin supplementation enhanced the immune responses of the treated fish, which was evidenced by the increased globulin, total protein, respiratory burst activity, and total immunoglobulin levels. The highest expression levels of the il-8, il-1β, TGF-β, and SAA genes was noticed in the C7 group, as compared with the results for the other groups. The IgT gene expression levels were higher in all experimental groups than in the CT group, and this increase was at the highest level in the C28 group. Following the bacterial challenge, all experimental groups displayed higher survival rates compared to that of the CT group. These values were 75.93, 72.22, 46.30, 33.33, and 29.63% in the C7, C14, C21, C28, and CT groups, respectively, with the C7 group displaying the highest survival rate among the groups. The histological examination of liver and head kidney tissues revealed that higher doses (in the C21 and C28 groups) showed an increase in cytoplasmic vacuolization, which causes adverse effects on fish health. However, the C7 group displayed normal histological structure in both tissues. Taken together, the most favorable immune responses were achieved in the C7 group, suggesting that 0.7% oleoresin could be applied to rainbow trout to boost immunity and protect the fish from diseases. Full article

(This article belongs to the Special Issue Enhancing Aquatic Animal Health Through Feed Additives)

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27 pages, 3080 KiB

Open AccessSystematic Review

Effects of the COVID-19 Pandemic on Early Childhood Development and Mental Health: A Systematic Review and Meta-Analysis of Comparative Studies

by Sasha Alcon, Sa Shen, Hong-nei Wong, Cynthia R. Rovnaghi, Leni Truong, Jordan K. H. Vedelli and Kanwaljeet J. S. Anand

Psychol. Int. 2024, 6(4), 986-1012; https://doi.org/10.3390/psycholint6040062 - 25 Nov 2024

Abstract

From 2020 to 2023, the coronavirus-19 (COVID-19) pandemic exposed children to a variety of adverse childhood events, including parental loss, abuse, and disruption in services, and it exacerbated societal inequities. Studies evaluating the mental health of older children and adolescents reported increases in [...] Read more.

From 2020 to 2023, the coronavirus-19 (COVID-19) pandemic exposed children to a variety of adverse childhood events, including parental loss, abuse, and disruption in services, and it exacerbated societal inequities. Studies evaluating the mental health of older children and adolescents reported increases in depression and anxiety symptoms, but no reviews have addressed the effects of the pandemic on preschool children. This systematic review and meta-analysis is the first to explore these effects. The goal was to analyze and synthesize longitudinal cohort studies to determine impact of the COVID-19 pandemic on the development and mental health of young children. Searches of multiple databases were performed for studies published between 2018 and 2023 with pre- and post-pandemic evaluations of the mental health or development of preschool children (aged 0–6 years) using objective measures and according to Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Cohen’s d effect sizes were calculated for each study that utilized the Strengths and Difficulties Questionnaire (SDQ), Ages and Stages Questionnaire (ASQ), or the Child Behavior Checklist (CBCL). Random-effects mixed models combined the estimates of effect sizes to calculate the overall mean effect size. The meta-analyses included 22,348 children from 16 countries. The analyses showed small increases in emotional symptoms and conduct problems, as well as increases in emotional reactivity, anxiety/depression, withdrawal symptoms, attention problems, and aggressive behaviors. A decrease in fine motor and personal–social skills was noted. Studies not included in these meta-analyses also showed negative effects on language and executive function. This systematic review characterizes the detrimental effects of the COVID-19 pandemic on the mental health and development of preschool children across the world. Our results suggest the vulnerability of early childhood to pandemic-related disruptions, although the heterogeneity in study design and child characteristics may limit some of these conclusions. Full article

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7 pages, 1504 KiB

Open AccessCase Report

The Successful Use of Extracorporeal Membrane Oxygenation in a Newly Diagnosed HIV Patient with Acute Respiratory Distress Syndrome (ARDS) Complicated by Pneumocystis and Cytomegalovirus Pneumonia: A Case Report

by Jin Kook Kang, Matthew Acton and Bo Soo Kim

Emerg. Care Med. 2024, 1(4), 428-434; https://doi.org/10.3390/ecm1040042 - 25 Nov 2024

Abstract

Background: We report a case of an adult patient with newly diagnosed human immunodeficiency virus (HIV) infection, acquired immune deficiency syndrome (AIDS), and acute respiratory distress syndrome (ARDS) secondary to pneumocystis and cytomegalovirus pneumonia that were present on presentation, which were successfully managed [...] Read more.

Background: We report a case of an adult patient with newly diagnosed human immunodeficiency virus (HIV) infection, acquired immune deficiency syndrome (AIDS), and acute respiratory distress syndrome (ARDS) secondary to pneumocystis and cytomegalovirus pneumonia that were present on presentation, which were successfully managed with venovenous extracorporeal membrane oxygenation (VV-ECMO). Case Presentation: A 40-year-old patient with a past medical history of asthma was admitted to a local hospital due to dyspnea, cough, and wheezing, where the patient was diagnosed with HIV infection, ARDS, and combined pneumocystis and cytomegalovirus pneumonia. Their pulmonary function quickly declined, necessitating mechanical ventilation (MV). After all conventional therapies failed, the patient was transferred to a tertiary medical center for VV-ECMO therapy. The patient was successfully treated with antiretroviral therapy (ART), antibiotics, antivirals, steroids, and 48 days of VV-ECMO support, with complete resolution of their respiratory symptoms. The patient was discharged on hospital day 82. Conclusions: HIV-positive patients with ARDS that is complicated by opportunistic pulmonary infections can be successfully managed with ART, appropriate anti-infective therapies, and VV-ECMO. Full article

(This article belongs to the Special Issue Emergency Medicine Update: Cardiopulmonary Resuscitation)

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9 pages, 229 KiB

Open AccessReview

Advancements in Respiratory Surgery Anesthesia: A Collaborative Approach to Perioperative Management and Recovery

by Nobuyasu Komasawa

Anesth. Res. 2024, 1(3), 204-212; https://doi.org/10.3390/anesthres1030019 - 25 Nov 2024

Abstract

Thoracic surgery is a highly complex field requiring collaboration between surgeons, anesthesiologists, pulmonologists, and other specialists. Successful outcomes depend on thorough preoperative evaluations that consider the patient’s overall health, lifestyle habits, and surgical risks. Key elements include proper intraoperative anesthesia management, postoperative pain [...] Read more.

Thoracic surgery is a highly complex field requiring collaboration between surgeons, anesthesiologists, pulmonologists, and other specialists. Successful outcomes depend on thorough preoperative evaluations that consider the patient’s overall health, lifestyle habits, and surgical risks. Key elements include proper intraoperative anesthesia management, postoperative pain control, and the integration of enhanced recovery after surgery (ERAS) protocols to optimize recovery. Double-lumen tubes (DLTs) are essential for one-lung ventilation during thoracic procedures, although they can be invasive. Recent advancements, such as video-assisted laryngoscopes, have improved the success of DLTs and reduced the invasiveness of DLT intubation and extubation. Postoperative pain management is crucial for minimizing complications and enhancing recovery. Techniques like epidural analgesia, nerve blocks, and patient-controlled analgesia improve patient outcomes by allowing early mobility and deep breathing. Dexmedetomidine (DEX), a sedative with minimal respiratory impact, has shown promise in reducing delirium and aiding recovery. This review highlights the importance of teamwork, pain management, and emerging technologies in improving thoracic surgery outcomes. Advances in these areas, particularly within ERAS protocols, continue to enhance patient care and overall surgical success. Full article

25 pages, 3282 KiB

Open AccessReview

Breast Cancer Treatment: The Potential of Organic and Inorganic Nanocarriers in Targeted Drug Delivery

by Saravanan Alamelu, Kamalesh Balakumar Venkatesan, Kalist Shagirtha, Manoj Kumar Srinivasan, Chellasamy Panneerselvam, Al Thabiani Aziz, Mohammed Ali Alshehri, Mohamed Ali Seyed and Pugalendhi Pachaiappan

Drugs Drug Candidates 2024, 3(4), 813-837; https://doi.org/10.3390/ddc3040046 - 25 Nov 2024

Abstract

Breast cancer (BC) is the most prevalent form of malignancy among women on a global scale, ranking alongside lung cancer. Presently, conventional approaches to cancer treatment include surgical procedures followed by chemotherapy or radiotherapy. Nonetheless, the efficacy of these treatments in battling BC [...] Read more.

Breast cancer (BC) is the most prevalent form of malignancy among women on a global scale, ranking alongside lung cancer. Presently, conventional approaches to cancer treatment include surgical procedures followed by chemotherapy or radiotherapy. Nonetheless, the efficacy of these treatments in battling BC is often compromised due to the adverse effects they inflict on healthy tissues and organs. In recent times, a range of nanoparticles (NPs) has emerged, exhibiting the potential to specifically target malignant cells while sparing normal cells and organs from harm. This has paved the way for the development of nanoparticle-mediated targeted drug delivery systems, holding great promise as a technique for addressing BC. To increase the efficacy of this new method, several nanocarriers including inorganic NPs (such as magnetic NPs, silica NPs, etc.) and organic NPs (e.g., dendrimers, liposomes, micelles, and polymeric NPs) have been used. Herein, we discuss the mechanism of NP-targeted drug delivery and the recent advancement of therapeutic strategies of organic and inorganic nanocarriers for anticancer drug delivery in BC. We also discuss the future prospects and challenges of nanoparticle-based therapies for BC. Full article

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19 pages, 2247 KiB

Open AccessArticle

Diode Laser Absorption Spectroscopy and DSMC Calculations for the Determination of Species-Specific Diffusion Coefficients of a CO₂-N₂O Gas Mixture in the Transition Gas Regime

by Kannan Munusamy, Harald Kleine and Sean O’Byrne

Spectrosc. J. 2024, 2(4), 287-305; https://doi.org/10.3390/spectroscj2040017 - 25 Nov 2024

Abstract

Multicomponent gas mixture diffusion in a microscale confined flow in the transition gas regime at Knudsen numbers (Kn) above 0.1 has potential engineering applications in gas-phase microfluidics. Although the calculation of the diffusion coefficient accounts for the influence of the concentration of other [...] Read more.

Multicomponent gas mixture diffusion in a microscale confined flow in the transition gas regime at Knudsen numbers (Kn) above 0.1 has potential engineering applications in gas-phase microfluidics. Although the calculation of the diffusion coefficient accounts for the influence of the concentration of other species in a multicomponent gas mixture, the higher rate of gas-wall collision at 0.1 < Kn ≤ 10 introduces additional complications not predicted by conventional calculation methods. Thus, simultaneous measurement of diffusion coefficients for multiple gas species ensures accurate estimation of the diffusion coefficient of a particular species that includes the effect of interactions with other species and wall surface conditions in a multicomponent gas mixture at Kn > 0.1. However, most experimental methods for measuring the diffusion coefficient are not species-specific and therefore cannot directly differentiate between the species diffusing in a gas mixture. Thus, this paper demonstrates a new experiment methodology consisting of a two-bulb diffusion configuration accompanied by a tunable diode laser absorption spectroscopy detection technique for species-specific, in-situ, simultaneous measurement of the effective diffusion coefficient for a CO₂-N₂O gas mixture in the transition gas regime. The experimental results are compared against direct simulation Monte Carlo calculations and the Bosanquet approximation showing a deviation that has not been reported in the literature before. Full article

(This article belongs to the Special Issue Feature Papers in Spectroscopy Journal)

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14 pages, 15922 KiB

Open AccessArticle

Influence of Subsequent Heat Treatment on Fatigue Behavior of Shear-Cut Electrical Steel Sheets

by Albin Gottwalt-Baruth, Paul Kubaschinski, Manuela Waltz and Ulrich Tetzlaff

Alloys 2024, 3(4), 281-294; https://doi.org/10.3390/alloys3040017 - 25 Nov 2024

Abstract

The fatigue behavior of a fully processed, non-oriented electrical steel sheet is investigated in dependence on shear-cutting parameters and a subsequent heat treatment. For this, stress-controlled fatigue tests are performed before and after annealing at 700 °C for a total of six different [...] Read more.

The fatigue behavior of a fully processed, non-oriented electrical steel sheet is investigated in dependence on shear-cutting parameters and a subsequent heat treatment. For this, stress-controlled fatigue tests are performed before and after annealing at 700 °C for a total of six different shear-cutting settings. For all parameters, the fatigue strength of shear-cut sheets is improved by the heat treatment. This is due to reduction in a large part of the strain hardening region as well as the reduction in tensile residual stresses. Both were introduced during shear cutting and act detrimental to the fatigue strength. However, the intensity of this improvement depends on the shear-cutting parameters. This is related to the corresponding edge surfaces characteristically being formed during shear cutting. Specimens cut with a worn cutting tool show a more pronounced increase in fatigue life. In contrast, specimens produced with a sharp-edged cutting tool and high cutting clearance hardly benefit from the heat treatment. This appears to be caused by differences in surface topography, in particular coarse topographical damage in the form of grain breakouts. If these occur during shear cutting, the crack formation is not significantly delayed by additional annealing. Full article

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32 pages, 842 KiB

Open AccessReview

A Scoping Review of Tools to Assess Digital Health Literacy Among Middle-Aged and Older Adults for Application to Dietetic Practice

by Jingyi Jess Bai, Mariam Mandoh, Yee Mei Yu and Margaret Allman-Farinelli

Dietetics 2024, 3(4), 523-554; https://doi.org/10.3390/dietetics3040037 - 25 Nov 2024

Abstract

Medical Nutrition Therapy (MNT) services have shifted from only in-person to digital consultations. This may present a challenge to older patients if they are not digitally literate. This scoping review aimed to identify and analyse tools for assessing digital health literacy to guide [...] Read more.

Medical Nutrition Therapy (MNT) services have shifted from only in-person to digital consultations. This may present a challenge to older patients if they are not digitally literate. This scoping review aimed to identify and analyse tools for assessing digital health literacy to guide dietetic practice in screening patients for digital care needs and training. Publications that used or tested a digital health literacy tool with participants aged 45 years and older in clinical, community, or population settings were deemed eligible. Five scientific databases, reference lists of identified studies, and publications from key authors were searched for peer-reviewed articles published in English between 2014 and March 2024. Relevant data on participant characteristics, tool design, and validation were charted. The generalisability of studies and applicability of tools were assessed using 4-point scales. Searches yielded 1823 articles, of which 66 articles were included in the final analysis. Eight tools were identified, and the electronic Health Literacy Scale (eHEALS) was the most frequently used. After evaluating the validity and feasibility of these tools, the adapted eHEALS emerged as the most applicable for digitally delivered MNT. Future studies should explore effective educational programmes for less digitally literate populations to better connect them to online MNT healthcare services. Full article

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20 pages, 11056 KiB

Open AccessProject Report

Highly Permeable, Electrically Switchable Filter for Multidimensional Sorting of Suspended Particles

by Laura Weirauch, Jasper Giesler, Georg R. Pesch, Michael Baune and Jorg Thöming

Powders 2024, 3(4), 574-593; https://doi.org/10.3390/powders3040030 - 25 Nov 2024

Abstract

The creation of highly specific particle systems in the nano- and micrometer size range is a challenging task. The demand for particle systems with narrowly distributed properties is increasing in many applications, especially for use in high-tech products. Conventional separation techniques often reach [...] Read more.

The creation of highly specific particle systems in the nano- and micrometer size range is a challenging task. The demand for particle systems with narrowly distributed properties is increasing in many applications, especially for use in high-tech products. Conventional separation techniques often reach their limits in the micrometer size range or become (labor-)intensive, which makes them economically or ecologically unsustainable. In addition, sorting based on several properties is rarely feasible in just one separator. Dielectrophoretic processes can be a viable option for complex sorting tasks like this, given their ability to address several particle properties and their high degree of selectivity. In this paper, we summarize the progress of a project in which the capability of dielectrophoretic methods for multidimensional sorting of microparticles was investigated. We were able to develop an operation mode for multidimensional sorting of microparticles using dielectrophoresis as well as a scalable electrically switchable filter. This creates a basis for high-throughput and multi-target sorting of technical microparticles using dielectrophoretic processes. Full article

(This article belongs to the Collection Multidimensional Particle Properties: Characterization, Description, Separation)

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10 pages, 3355 KiB

Open AccessArticle

Rapid Onset of Innate Response, Cytokine Signaling and Humoral Immunity in Inactivated LPAI-H9N2-Vaccinated Broilers

by Ismail A. Raheel, Ahmed R. Elbestawy, Mohamed S. Diab, Mervat A. Abdel-Latif, Nehal Tag and Ahmed Orabi

Poultry 2024, 3(4), 420-429; https://doi.org/10.3390/poultry3040032 - 25 Nov 2024

Abstract

The development of effective and innovative vaccination strategies is urgently needed to better control the spread and transmission of the low-pathogenic avian influenza H9N2 subtype (LPAI-H9N2) in poultry. In addition, the enhancement of innate immunity by some of these innovative inactivated vaccines has [...] Read more.

The development of effective and innovative vaccination strategies is urgently needed to better control the spread and transmission of the low-pathogenic avian influenza H9N2 subtype (LPAI-H9N2) in poultry. In addition, the enhancement of innate immunity by some of these innovative inactivated vaccines has not yet been investigated. Here, an experiment was conducted in commercial broiler chickens to compare the immune response to two different inactivated H9N2 vaccines. For this, Group 1 (G1) broilers were vaccinated with vaccine 1 [Nobilis^® H9N2-P (pathogen-associated molecular patterns—PAMP) technology], broilers in G2 were vaccinated with vaccine 2 [an inactivated whole H9N2 virus (IWV) autogenous oil emulsion vaccine], while birds in G3 were not vaccinated. The study lasted 34 days. Innate immune parameters (phagocytic activity, nitric oxide, and lysozyme), cytokine signaling (IL-1β, IL-6, IL-8), humoral immunity using the hemagglutination inhibition (HI) test, and the gene expressions of IFN-γ and TLR-21 were assessed. The results showed a significant increase in innate immunity and modulatory cytokines at 24–48 h after the vaccination of G1 broilers, with a continuous increase until the end of the experiment. In addition, a significant increase in geometric mean HI titers was observed in G1 at 11 days post-vaccination (dpv), and a significant (p ˂ 0.05) upregulation of IFN-γ and TLR-21 was observed in the same group, G1, at 31 dpv compared to G2 and G3. Nobilis^® H9N2-P may induce faster and stronger innate and active humoral immunity compared to another IWV, which may contribute to the protection of broilers against early H9N2 infections. However, challenge protection studies for several IWV vaccines, including PAMP-H9N2 against LPAI-H9N2, should be further evaluated in both specific pathogen-free (SPF) and commercial broilers. Full article

(This article belongs to the Special Issue Current Research and Key Issues in Poultry Immunology)

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21 pages, 3757 KiB

Open AccessArticle

Using Virtual Reality Recreation Therapy to Enhance Social Interaction and Well-Being in Homebound Seniors

by Jonathan J. Foo, Keng Hao Chew, Peggy Lim, June Tay and Carol Hok Ka Ma

J. Ageing Longev. 2024, 4(4), 373-393; https://doi.org/10.3390/jal4040027 - 25 Nov 2024

Abstract

In view of Singapore’s rapidly ageing population, this study is an exploratory pilot designed to assess the feasibility and potential impact of virtual reality recreation therapy (VRRT) on homebound seniors. A tri-party research partnership was formed between the Singapore University of Social Sciences [...] Read more.

In view of Singapore’s rapidly ageing population, this study is an exploratory pilot designed to assess the feasibility and potential impact of virtual reality recreation therapy (VRRT) on homebound seniors. A tri-party research partnership was formed between the Singapore University of Social Sciences (SUSS), NTUC Health Home Care, and Vue Reality Labs. The aim was to explore the benefits of VR recreation therapy for homebound seniors, contributing to the goal of ‘aging in place’. Over two years, a 52-week VR curriculum was developed, featuring social, travel, and cultural topics tailored to the seniors. Five care associates from NTUC Health Home Care received facilitator training by Vue Reality Labs. A total of 71 homebound senior participants aged 50 to 102 engaged in over 1600 session hours during the 52-week trial; 62% had varying levels of dementia. A mixed-methods approach was adopted to explore the general impact and feasibility of VR recreation therapy, incorporating quantitative data on participants’ emotional, social, and cognitive conditions and qualitative data from facilitator interviews. The findings revealed that most senior participants enjoyed the VR sessions, perceiving them to positively impact their overall health and well-being. Caregivers reported improvements in cognitive, social, and emotional functioning of the participants. The positive effects extended to caregivers and facilitators, with renewed relationships and enhanced skills, respectively. The insights and observations gathered from this pilot study will serve as a foundation for designing a more robust study for deploying the VR recreation therapy programme in senior care. Full article

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17 pages, 4643 KiB

Open AccessArticle

Validation of a Precise Impactor in a Rodent Cervical Spinal Cord Injury Hemi-Contusion Model

by Jose A. Castillo, Jr., Michael Nhien Le, Christopher Pivetti, Jordan E. Jackson, Edwin Kulubya, Zachary Paxton, Camille Reed, Khadija Soufi, Arash Ghaffari Rafi, Allan Martin, Richard Price, Kee Kim, Diana Farmer, Aijun Wang and Rachel Russo

BioMed 2024, 4(4), 524-540; https://doi.org/10.3390/biomed4040039 - 25 Nov 2024

Abstract

Background: Cervical spinal cord injuries (SCIs) are the most common type of human SCI. Although various animal SCI contusion models have been developed to mirror human pathology, few have described cervical-level injuries. This study aims to validate and establish optimal impact parameters to [...] Read more.

Background: Cervical spinal cord injuries (SCIs) are the most common type of human SCI. Although various animal SCI contusion models have been developed to mirror human pathology, few have described cervical-level injuries. This study aims to validate and establish optimal impact parameters to produce consistent incomplete cervical SCIs for testing novel therapies. Methods: Using a precise impactor, 3 cervical spinal cord hemi-contusions of varying severities were induced by modifying penetration depths and controlling dwell times. Penetration depths of 2.11 mm (n = 4), 2.24 mm (n = 4), and 2.36 mm (n = 3) were used with a dwell time of 0.05 s to create mild, moderate, and severe injuries. Behavioral assessments in weeks 1, 2, 5, and 8 included grooming test, forelimb asymmetry test, and the Irvine, Beatties, and Bresnahan forelimb scale (IBB). After 8 weeks, rats were euthanized, and spinal cord histology was performed. Results: Within each group, animals exhibited consistent motor deficits and functional recovery. Mean IBB scores varied significantly between each group at week 8 (p < 0.0001). Ipsilateral forelimb usage significantly improved throughout the study period in the mild (2.11 mm) and moderate (2.24 mm) groups, while the severely (2.36 mm) injured group continued to exhibit 100% asymmetrical forelimb usage. Conclusions: This study demonstrates that a precise impactor can create reproducible models of incomplete cervical SCIs. A penetration depth of 2.24 mm resulted in moderate injury with significant motor deficits that slowly improved over time, permitting future therapeutic studies in functional recovery. Full article

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29 pages, 4259 KiB

Open AccessReview

Climate Adaptation of Roads to Flooding Hazards—A Review

by Mehvesh Mushtaq, Marco Corradi and Shirsendu Sikdar

Constr. Mater. 2024, 4(4), 748-776; https://doi.org/10.3390/constrmater4040041 - 25 Nov 2024

Abstract

Flooding hazards due to climate change are increasingly becoming a frequent global occurrence. The aim of this study is to provide a comprehensive review of the various structural mitigation and adaptation strategies available to engineers and designers at various stages of road construction [...] Read more.

Flooding hazards due to climate change are increasingly becoming a frequent global occurrence. The aim of this study is to provide a comprehensive review of the various structural mitigation and adaptation strategies available to engineers and designers at various stages of road construction and rehabilitation to increase the resilience of roads to flooding damage. The criteria for categorising the various strategies available were the time of intervention with respect to the occurrence of the hazard. Thus, all studied strategies were separated into pre-construction design changes, post-construction mitigation and adaptation options like Sustainable Urban Drainage Systems (SuDS). The main findings were that changing the specifications of commonly used materials can provide increased flood resilience, and a preliminary design for flooding can reduce post-flooding rehabilitation. The study can be used as a guide for the different options available to deliver a design that takes flooding into consideration. Full article

10 pages, 6222 KiB

Open AccessArticle

Waste Polyethylene Terephthalate (PET) as a Partial Replacement of Aggregates in Sustainable Concrete

by Lukman Abubakar, Nusrat Yeasmin and Arjak Bhattacharjee

Constr. Mater. 2024, 4(4), 738-747; https://doi.org/10.3390/constrmater4040040 - 25 Nov 2024

Abstract

Concrete use is enhanced daily due to infrastructure development, but it has adverse impacts on the environment. Modern lifestyles have led to the increased use of plastic, and, for households, polyethylene terephthalate (PET) plastics are used. However, PET is non-biodegradable and causes adverse [...] Read more.

Concrete use is enhanced daily due to infrastructure development, but it has adverse impacts on the environment. Modern lifestyles have led to the increased use of plastic, and, for households, polyethylene terephthalate (PET) plastics are used. However, PET is non-biodegradable and causes adverse impacts on the environment and marine health. So, there is a need to minimize the amount of plastic waste by finding an alternative use for the waste. Our study focuses on creating sustainable concrete by utilizing PET-based plastic waste as a partial substitution for aggregates, aiming to use this concrete for various low-load-bearing construction applications. From our phase analysis study, no adverse effects were found on cement phase formation. We also found that up to 10 wt.% PET incorporation leads to acceptable compressive strength reduction as per ASTM guidelines. To enhance adhesion, the PET was roughened, and, from FESEM, we found effective adhesion of PET waste into the cement matrix. We believe that this sustainable concrete will not only contribute to waste reduction but also promote eco-friendly construction material development. Full article

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19 pages, 4171 KiB

Open AccessArticle

Exploration of the Topical Nanoemulgel Bearing with Ferulic Acid and Essential Oil for Diabetic Wound Healing

by Urati Anuradha, Valamla Bhavana, Padakanti Sandeep Chary, Nitin Pal Kalia and Neelesh Kumar Mehra

Pathophysiology 2024, 31(4), 680-698; https://doi.org/10.3390/pathophysiology31040049 - 25 Nov 2024

Abstract

Aim: To investigate the anti-inflammatory, antioxidant, and diabetic wound healing properties of the novel topical formulation [Ferulic acid-loaded nanoemulgel (DLMGO-G)]. Methods: Ferulic acid nanoemulsion developed with lemongrass oil is investigated in diabetic wound healing. Further nanoemulsion is incorporated into 1% carbopol^® 934 [...] Read more.

Aim: To investigate the anti-inflammatory, antioxidant, and diabetic wound healing properties of the novel topical formulation [Ferulic acid-loaded nanoemulgel (DLMGO-G)]. Methods: Ferulic acid nanoemulsion developed with lemongrass oil is investigated in diabetic wound healing. Further nanoemulsion is incorporated into 1% carbopol^® 934 to obtain the DLMGO-G. Nanoemulsion was characterized for particle size, and polydispersity index (PDI) was obtained by Malvern Zetasizer (Zetasizer Nano ZS, Malvern, AL, USA), and morphology by TEM (JEM 1400, JOEL, Akishima, Japan). Furthermore, in vitro cell line and in vivo studies were carried out. Results: The developed nanoemulsion showed a globule size of 28.04 ± 0.23 nm and PDI of 0.07 ± 0.01. The morphology of nanoformulations by TEM confirmed the spherical and uniform nature. Further, the nanoformulation in in vitro cell line experiments revealed that the IC50 value was increased by 1.52 times compared to the drug solution. The treatment groups have shown that fibroblast morphologies were spindle-shaped, suggesting that nanoformulation was compatible with the cells and developed normally on nanoformulation. It also reduced ROS with improved internalization more than the control group. The in vitro wound healing model also revealed that nanoformulation had better wound healing activity. In the in vivo diabetic wound studies on male SD rats, the levels of inflammatory markers such as TNF-α, IL-6, IL-22, and IL-1β declined significantly when treated with DLMGO-G. IL-10 levels significantly increased compared to the diseased group, and MMP-9 levels were remarkably decreased compared to the diseased group. Furthermore, histopathological studies showed the regeneration and granulation of tissues. Conclusions: Thus, these findings indicate that FA-loaded nanoemulgel greatly accelerates the healing of wounds in diabetic rats. Full article

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21 pages, 2551 KiB

Open AccessArticle

Sustainable Enzymatic Production of Bioactive Compounds: From Designing to Bioavailability

by Raquel Neves and Maria H. L. Ribeiro

Compounds 2024, 4(4), 708-728; https://doi.org/10.3390/compounds4040043 - 25 Nov 2024

Abstract

This study evaluates the feasibility and effectiveness of using immobilized pectinase enzymes for juice processing to reduce cloudiness while preserving nutritional and bioactive properties. The research is driven by the increasing demand for innovative food products that offer enhanced functionality and health benefits. [...] Read more.

This study evaluates the feasibility and effectiveness of using immobilized pectinase enzymes for juice processing to reduce cloudiness while preserving nutritional and bioactive properties. The research is driven by the increasing demand for innovative food products that offer enhanced functionality and health benefits. It focuses on the development and application of immobilized biocatalysts in bioprocessing, specifically using pectinase encapsulated in a sol–gel matrix. Reaction parameters for the interaction between immobilized pectinase and its primary substrate, pectin, were optimized through systematic experimentation. Optimal conditions were established, achieving enhanced enzyme activity and stability with 0.15 g of lens-shaped capsules containing 10.0 mg/mL pectinase in 24-well microplates as microreactors. Kinetic studies indicated improved substrate affinity after immobilization (K_m = 0.115 mg/mL), particularly when magnetized (K_mi = 0.041 mg/mL). Operational stability and reusability assessments demonstrated potential for extended use with magnetized pectinase capsules retaining higher residual activity after a fourth reuse cycle (155% > 75%). The application of immobilized pectinase in processing peach nectar successfully reduced cloudiness and increased the release of bioactive compounds, enhancing antioxidant and anti-inflammatory activities, as evaluated by the DPPH (2,2-diphenyl-1-picrylhydrazyl) assay and the albumin method, respectively. In vitro digestion studies revealed dynamic activity profile changes, highlighting the impact of juice bioprocessing on bioavailability. Full article

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13 pages, 6262 KiB

Open AccessArticle

The Ni₃Al/Ni Interfacial Contribution to the Indentation Size Effect of Ni-Based Single-Crystal Superalloys

by Zhiwei Zhang, Xingyi Zhang, Rong Yang, Jun Wang and Chunsheng Lu

Solids 2024, 5(4), 580-592; https://doi.org/10.3390/solids5040039 - 25 Nov 2024

Abstract

Hardness decreases as indentation depth increases at both the nano- and micro-meter scales. By incorporating interfacial contributions, the indentation size effect can provide valuable information on the deformation behaviors of Ni-based single-crystal superalloys. In this paper, through experimental studies and atomistic simulations, we [...] Read more.

Hardness decreases as indentation depth increases at both the nano- and micro-meter scales. By incorporating interfacial contributions, the indentation size effect can provide valuable information on the deformation behaviors of Ni-based single-crystal superalloys. In this paper, through experimental studies and atomistic simulations, we examine the indentation size effect and mechanical behaviors of Ni-based single-crystal superalloys. The results demonstrate that the indentation size effect, in conjunction with the Ni₃Al/Ni interfacial network, is effectively captured by a modified Nix–Gao model. Molecular dynamics simulations further reveal the underlying atomistic mechanisms and microstructural evolution during nanoindentation. These findings provide new insights into the deformation behavior of Ni-based single-crystal superalloys and support their wide applications in the aerospace industry. Full article

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16 pages, 1271 KiB

Open AccessArticle

Impact of Geographic Location on Risks of Fintech as a Representative of Financial Institutions

by Yelena Popova, Olegs Cernisevs and Sergejs Popovs

Geographies 2024, 4(4), 753-768; https://doi.org/10.3390/geographies4040041 - 25 Nov 2024

Abstract

The activities of contemporary financial institutions require significant geographic expansion. Even the increased level of industry digitalisation does not minimise the importance of the physical assets of financial institutions. The environmental factors specific to each geographic region can significantly influence the efficiency of [...] Read more.

The activities of contemporary financial institutions require significant geographic expansion. Even the increased level of industry digitalisation does not minimise the importance of the physical assets of financial institutions. The environmental factors specific to each geographic region can significantly influence the efficiency of operations of financial institutions. The goal of the article is to determine the impact of the geographic location of physical assets via environmental risks affecting the other risks of fintech as a representative of financial institutions. The impact is determined by the employment of the PLS-SEM model implemented in SmartPLS 4.0 software. The model determines the impact of environmental risks on governance risks, operational risks, human resources and safety risks, ICT risks, compliance risks, and strategic risks. These groups of risks form the latent variables, which comprise the experts’ estimation of threats and vulnerabilities impacts and their likelihoods. After testing five hypotheses, two of them were supported—environmental risks impact human resources safety risks and operational risks. Full article

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26 pages, 5497 KiB

Open AccessArticle

Transient Stability-Based Fast Power System Contingency Screening and Ranking

by Teshome Lindi Kumissa and Fekadu Shewarega

Electricity 2024, 5(4), 947-971; https://doi.org/10.3390/electricity5040048 - 25 Nov 2024

Abstract

Today’s power systems are operated closer to their stability limits due to the continuously growing load demands, interface to open markets, and integration of more renewable energies. In order to provide operators with clear insight on the current system situation, near real-time power [...] Read more.

Today’s power systems are operated closer to their stability limits due to the continuously growing load demands, interface to open markets, and integration of more renewable energies. In order to provide operators with clear insight on the current system situation, near real-time power systems dynamic security assessment tools are required. One of the core elements of near real-time dynamic security assessment tools is contingency screening and ranking. Most of the commercially available tools screen and rank contingencies by using the traditional numerical integration or Transient Energy Functions (TEFs) or hybrid methods. The traditional numerical integration method is accurate but computationally intensive and has a slow assessment speed which makes it difficult to identify any insecure contingency before it happens. Despite the TEF method of transient stability analysis being relatively fast, it develops less accurate results due to models simplification and assumptions. This paper introduces transient stability based on fast and robust contingency screening and ranking using an Adaptive step-size Differential Transformation (AsDTM) method. Based on the most current snapshot from Supervisory Control and Data Accusation (SCADA) data, the proposed method triggers AsDTM-based transient stability simulation for each credible contingency and evaluates Transient Stability Indices (TSI) as the normalized weighted sum of squares of errors derived from state variables and complex bus voltages at every simulation time step. Finally, contingencies are ranked based on these TSI and the worst contingency is identified for the next detail assessment. The method is tested on IEEE 9 bus and 39 bus test systems. Test results reveal that the proposed method is faster, robust, and can be used in near real-time dynamic security assessment sessions. Full article

(This article belongs to the Special Issue Advances in Operation, Optimization, and Control of Smart Grids)

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9 pages, 4793 KiB

Open AccessReview

“Chasing Rainbows” Beyond Kaposi Sarcoma’s Dermoscopy: A Mini-Review

by Emmanouil Karampinis, Olga Toli, Georgia Pappa, Anna Vardiampasi, Melpomeni Theofili, Efterpi Zafiriou, Mattheos Bobos, Aimilios Lallas, Elizabeth Lazaridou, Biswanath Behera and Zoe Apalla

Dermatopathology 2024, 11(4), 333-341; https://doi.org/10.3390/dermatopathology11040035 - 25 Nov 2024

Abstract

The dermoscopic rainbow pattern (RP), also known as polychromatic pattern, is characterized by a multicolored appearance, resulting from the dispersion of polarized light as it penetrates various tissue components. Its separation into different wavelengths occurs according to the physics principles of scattering, absorption, [...] Read more.

The dermoscopic rainbow pattern (RP), also known as polychromatic pattern, is characterized by a multicolored appearance, resulting from the dispersion of polarized light as it penetrates various tissue components. Its separation into different wavelengths occurs according to the physics principles of scattering, absorption, and interference of light, creating the optical effect of RP. Even though the RP is regarded as a highly specific dermoscopic indicator of Kaposi’s sarcoma, in the medical literature, it has also been documented as an atypical dermoscopic finding of other non-Kaposi skin entities. We aim to present two distinct cases—a pigmented basal cell carcinoma (pBCC) and an aneurysmatic dermatofibroma—that exhibited RP in dermoscopy and to conduct a thorough review of skin conditions that display RP, revealing any predisposing factors that could increase the likelihood of its occurrence in certain lesions. We identified 33 case reports and large-scale studies with diverse entities characterized by the presence of RP, including skin cancers (Merkel cell carcinoma, BCC, melanoma, etc.), adnexal tumors, special types of nevi (blue, deep penetrating), vascular lesions (acroangiodermatitis, strawberry angioma, angiokeratoma, aneurismatic dermatofibromas, etc.), granulation tissue, hypertrophic scars and fibrous lesions, skin infections (sporotrichosis and cutaneous leishmaniasis), and inflammatory dermatoses (lichen simplex and stasis dermatitis). According to our results, the majority of the lesions exhibiting the RP were located on the extremities. Identified precipitating factors included the nodular shape, lesion composition and vascularization, skin pigmentation, and lesions’ depth and thickness. These parameters lead to increased scattering and interference of light, producing a spectrum of colors that resemble a rainbow. Full article

(This article belongs to the Special Issue Associations between Dermoscopy and Dermatopathology)

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18 pages, 7264 KiB

Open AccessArticle

Microseismicity-Based Modelling of Induced Fracture Networks in Unconventional Reservoirs

by Tri Pham, Tan Bui-Thanh and Quoc Nguyen

Fuels 2024, 5(4), 839-856; https://doi.org/10.3390/fuels5040047 - 25 Nov 2024

Abstract

A single planar hydraulic fracture is typically the primary component used to simulate hydraulic fracturing stimulation in conventional reservoirs. However, in ultra-low-permeability shale reservoirs, a large system of fracture networks must be generated to produce hydrocarbons economically. Therefore, traditional modeling approaches centered on [...] Read more.

A single planar hydraulic fracture is typically the primary component used to simulate hydraulic fracturing stimulation in conventional reservoirs. However, in ultra-low-permeability shale reservoirs, a large system of fracture networks must be generated to produce hydrocarbons economically. Therefore, traditional modeling approaches centered on single planar fractures are inadequate for accurately representing the intricate geometry and behavior of fractures in these reservoirs. In previous works, 2D fractal fracture networks (FFNs) have been used to generate sets of hydraulic and natural fractures based on microseismic event (MSE) data. Since microseismic data are retrieved in 3D space, the aforementioned model cannot accurately represent induced fracture properties. The objective of this paper is to study in detail the recently developed 2D FFN model and propose a novel solution by expanding the previous model to accommodate real 3D microseismic data. First, the definitions of the 2D FFN model are described, and associated calibration mechanisms are proposed. Next, the 3D FFN model and its calibration system are demonstrated. While the novel 3D calibration solution utilizes an identical matching concept to the 2D methodology, the residual distances between the nodes and the MSE are calculated in 3D spaces. Finally, a set of real microseismic data are used to calibrate the generation of 3D fractals using the proposed workflow. The interactions between microseismicity and fractured reservoir dynamics are represented through the integration of fractal fracture models and microseismic data. This work contributes to advancing the current understanding of hydraulic fracturing in unconventional reservoirs and provides a valuable framework for improving fracture modeling’s accuracy in reservoir engineering applications. Full article

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