3D Cell Culture Systems for Biomedical Research

Dear Colleagues,

Recently, 3D cell culture systems have become one of the most relevant models in biological research; they are employed in a broad range of studies, particularly in the human health field, and are often chosen over traditional 2D (monolayer) in vitro cell cultures. They have a spatial structure, which enables the possibility of cell–cell interactions, and the model’s scaffold surface can mimic the tissue microenvironment. Three-dimensional cell culture systems may be useful in the development of new biomaterials or for surface functionalisation, which is the basis for tissue engineering. Moreover, some 3D structures may provide alternative solutions for tumour in vitro models and act as a bridge between in vitro and in vivo investigations. 3D models have the potential to depict advanced scaffold-linked pathology conditions in tissues and serve as a model for the design of new therapies. Interdisciplinary techniques are greatly needed to evaluate and visualise these structures and the experimental results.

We hope that this Special Issue will provide significant insight into the most advanced 3D cell culture models and encourage researchers to share their unique research and models to enable us to better understand and project future research with more adequate models.

Dr. Agnieszka Rusak
Dr. Benita Wiatrak
Guest Editors

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• 3D
• scaffolds
• spheroids
• biomaterials
• tumour model
• bioengineering
• tissue regeneration
• regenerative medicine
• targeted therapies
• tissue mimics
• angiogenesis
• cancerogenesis
• drug development
• 3D printing
• material functionalisation