The Next Generation of Proteomics for Precision Medicine: Second Edition

Dear Colleagues,

Personalized and precision medicine strive to improve our comprehension and individualized management of disease predisposition, etiology, pathogenesis, onset and progression, treatment response and monitoring, and health outcomes through precise and robust measurements of clinical, personal, molecular, cellular, imaging, environmental, and behavioral factors related to human health and disease. While genomics has been at the forefront of many precision-medicine strategies and discoveries due to the major technological advancements in next-generation sequencing, recent emerging developments in proteomics have begun to have a major impact on precision medicine and are likely to push the limits of proteomics to the next level, ultimately leading to the interrogation of the entire proteome.

Proteins, not DNA or RNA, directly orchestrate the majority of a cell’s functions, and their dysregulations are the ultimate causes of human diseases and the primary targets of most drugs for therapeutic intervention. Protein biomarkers are used in the clinic for many diagnostic applications to diagnose diseases, predict disease development and progression, predict and monitor response to therapy, pair the right patients with the right treatments, and serve as early readouts of drug safety and efficacy.

This Special Issue titled “The Next Generation of Proteomics for Precision Medicine” will highlight and disseminate the latest cutting-edge and innovative developments and findings in this rapidly emerging research field and its applications for human diseases, diagnostics, and drug development. The themes to be covered will include the strengths and limitations of current proteomics technologies; the next generation of innovative proteomics platforms designed for comprehensive and in-depth proteomics; single-molecule protein sequencing; and single-cell proteomics; and the utility and application of proteomics for precision medicine, biomarker discovery, diagnostic development, and drug discovery.

For this thematic collection, we cordially invite researchers to contribute high-quality original research and review articles that cover any relevant topic in state-of-the-art proteomics topics and future perspectives of proteomics.

I look forward to receiving your contributions.

Dr. Towia Libermann
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• proteomics
• biomarkers
• next-generation protein sequencing
• diagnostics
• protein quantitative trait locus
• systems biology
• precision medicine

• The Next Generation of Proteomics for Precision Medicine in Biomolecules (8 articles)