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8.3
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Journals
Biomolecules
Special Issues
Role of Probiotics in Health and Disease
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Role of Probiotics in Health and Disease

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 684

Special Issue Editor

Dr. Hary Razafindralambo

E-Mail Website
Guest Editor
1. ProBioLab, Namur, Belgium
2. Gembloux Agro-Bio Tech, Liege University, B-5030 Gembloux, Belgium
Interests: physical chemistry of biological and food systems; prebiotic, probiotic and postbiotic characterization and applications; synergy and interaction research; biobased compounds; colloid and interfacial sciences; formulation; nutraceuticals; One Health approaches; nanoparticles
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Probiotics have emerged as a subject of considerable interest owing to their potential positive impacts on human health. When appropriately utilized, these living microorganisms demonstrate efficacy in preventing, alleviating, or treating various health conditions and diseases, including acute diarrhea, antibiotic-associated gastrointestinal side effects, lactose intolerance, and allergy manifestations. While the beneficial effects of probiotics are often attributed to their role in restoring gut balance and microbial diversity, improving the gut barrier, producing metabolites that aid digestion and nutrient absorption, and enhancing the immune system response, the comprehensive understanding of their direct and indirect contributions in preventing cancers, viral infections, aging, antimicrobial resistance, etc., requires further broadening. This Special Issue is dedicated to gathering original articles that investigate the intricate role of probiotics of all generations in human health and disease. The selection of high-quality contributions of this Special Issue aims to expand the body of knowledge surrounding probiotics. By elucidating their functionalities, the publications offer valuable insights for healthcare practitioners, facilitating the tailoring of probiotic interventions for improved health outcomes. Furthermore, the presented findings may pave the way for the development of targeted probiotic formulations, offering preventive or therapeutic strategies for a diverse range of health conditions. 

Dr. Hary Razafindralambo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • human well-being
  • digestive health
  • immune system response
  • prevention
  • treatment

Published Papers (1 paper)

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Research

13 pages, 7119 KiB  
Article
Efficacy of the Probiotic L. brevis in Counteracting the Demineralizing Process of the Tooth Enamel Surface: Results from an In Vitro Study
by Serena Altamura, Francesca Rosaria Augello, Eleonora Ortu, Davide Pietropaoli, Benedetta Cinque, Mario Giannoni and Francesca Lombardi
Biomolecules 2024, 14(5), 605; https://doi.org/10.3390/biom14050605 - 20 May 2024
Viewed by 475
Abstract
Background. Enamel plays an essential role in protecting the underlying layers of the human tooth; therefore, preserving it is vital. This experimental study aimed to evaluate the potential ability of L. brevis to counteract the action of a demineralizing agent on dental enamel [...] Read more.
Background. Enamel plays an essential role in protecting the underlying layers of the human tooth; therefore, preserving it is vital. This experimental study aimed to evaluate the potential ability of L. brevis to counteract the action of a demineralizing agent on dental enamel morphology and mineral composition in vitro. Methods. The sample consisted of 12 healthy human posterior teeth. The coronal portion of each tooth was subdivided into two equal parts longitudinally. The specimens were randomly divided into four groups: artificial saliva, L. brevis suspension, demineralizing agent (DA), and DA plus L. brevis. Scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS) were used to evaluate the surface micromorphology and the mineral content, respectively. The statistical analysis was conducted using a one-way ANOVA, followed by Tukey’s post hoc test. Results. SEM analysis did not highlight significant changes in the enamel microstructure of L. brevis-treated specimens compared to the control. DA-induced damage to the enamel structure was drastically reduced when the specimens were contextually exposed to the probiotic. The treatment with DA substantially reduced the weight % of crucial enamel minerals, i.e., Ca and P. Notably, the probiotic was able to reverse the demineralization process, bringing Ca and P weight % back to basal levels, including the Ca/P ratio. Conclusions. The findings indicate that L. brevis is able to efficiently protect the dental enamel surface from the damage caused by DA and increase the enamel resistance to demineralization. Overall, L. brevis confirms its efficacy in preventing or counteracting the action of carious lesions through a novel mechanism that protects the tooth surface under a chemical challenge that mimics the caries process. Full article
(This article belongs to the Special Issue Role of Probiotics in Health and Disease)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: the symbiotic effect of Clostridium butyricum and wheat-derived arabinoxylan on inflammation in a mouse model of chronic colitis
Authors: Yukihiro Furusawa
Affiliation: Toyama Prefectural University

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