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Gastrointestinal Disorders
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Factors Affecting Disease Activity in Children and Adults with Inflammatory...
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Factors Affecting Disease Activity in Children and Adults with Inflammatory Bowel Disease: An Exploration of Pro-Inflammatory and Anti-Inflammatory Elements

A special issue of Gastrointestinal Disorders (ISSN 2624-5647).

Deadline for manuscript submissions: 30 September 2024 | Viewed by 1426

Special Issue Editors

Dr. Angharad Hurley (Vernon-Roberts)

E-Mail Website
Guest Editor
Department of Paediatrics, University of Otago Christchurch, Christchurch, New Zealand
Interests: paediatric; inflammatory bowel disease; functional gastrointestinal disorders; coeliac disease; outcome meausures; non-clinical outcomes
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Andrew Day

E-Mail Website
Guest Editor
Department of Paediatrics, Christchurch Hospital, University of Otago, Christchurch 4710, New Zealand
Interests: inflammatory bowel disease; coeliac disease; improving Crohn’s outcomes; intestinal inflammatory biomarkers; nutritional aspects of gut diseases; host–pathogen interactions in the gut (and how these relate to chronic gut diseases)
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

For children and adults with inflammatory bowel disease (IBD), the overarching aim of management is the induction and maintenance of remission, preferably with mucosal healing.  However, the disease course for each individual with IBD is unique and many different factors may increase clinical disease activity or prove to be beneficial (with improved activity or the prevention of relapse). This Special Issue provides a broad remit to discuss traditional and nuanced studies that explore well-known or little-known factors that could influence disease activity for those with IBD. Papers may report on anti-inflammatory factors that could include novel therapies, exercise, food and nutrition, complementary and alternative medicines, or traditional treatments. Work reporting pro-inflammatory factors may include psychosocial and environmental variables, drug interactions, or comorbid conditions. We welcome original studies, systematic reviews and meta-analyses, case-reports, and scoping reviews.

Dr. Angharad Hurley (Vernon-Roberts)
Prof. Dr. Andrew Day
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gastrointestinal Disorders is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • inflammatory bowel disease
  • disease activity
  • flare
  • remission
  • disease exacerbation
  • symptoms
  • clinical inflammation
  • triggers
  • pro-inflammatory
  • anti-inflammatory

Published Papers (2 papers)

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Review

15 pages, 1219 KiB  
Review
Role of IL-33/ST2 Pathway in Inflammatory Bowel Disease: An Overview and Future Perspectives
by Walter Giordano, Gabriele Ricciardi, Marco Casciaro, Vincenzo Fiorentino, Cristina Pizzimenti, Anna Viola, Maurizio Martini, Giovanni Tuccari and Antonio Ieni
Gastrointest. Disord. 2024, 6(2), 446-460; https://doi.org/10.3390/gidisord6020030 - 10 May 2024
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Abstract
Inflammatory bowel disease (IBD) represents a heterogenous and complex group of idiopathic chronic inflammatory conditions affecting the gastrointestinal tract and other extraintestinal systems with rising global incidences. The interplay of genetic predisposition and environmental factors contributes to its pathogenesis. Among the key cytokines [...] Read more.
Inflammatory bowel disease (IBD) represents a heterogenous and complex group of idiopathic chronic inflammatory conditions affecting the gastrointestinal tract and other extraintestinal systems with rising global incidences. The interplay of genetic predisposition and environmental factors contributes to its pathogenesis. Among the key cytokines implicated in IBD molecular alterations, IL-33 stands out for its multifaceted roles in both pathogenesis and repair mechanisms. IL-33, known for its action in initiating immune responses, is closely associated with Th2 immunity and is considered a potent inflammatory factor with dual functions, acting both as a pro-inflammatory cytokine and a transcriptional regulator. Primarily expressed by non-hematopoietic cells in the gastrointestinal tract, IL-33 interacts with its receptor, ST2, to modulate immune responses. In IBD, dysregulated IL-33 expression exacerbates mucosal inflammation, compromising barrier integrity and promoting tissue damage and fibrosis. Additionally, IL-33 plays a complex role in IBD-related colorectal cancer (CRC), affecting tumor progression and angiogenesis. This review summarizes the multifaceted roles of IL-33 in gastrointestinal health and disease, emphasizing its significance in the pathogenesis of IBD and CRC. Moreover, we thought it of interest to provide new insights into potential therapeutic avenues targeting IL-33 signaling for the management of these debilitating conditions. Full article
(This article belongs to the Special Issue Factors Affecting Disease Activity in Children and Adults with Inflammatory Bowel Disease: An Exploration of Pro-Inflammatory and Anti-Inflammatory Elements)
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15 pages, 1084 KiB  
Review
Gut Microbiota and Immune System in Necrotizing Enterocolitis and Related Sepsis
by Emilio Jirillo, Skender Topi, Ioannis Alexandros Charitos, Luigi Santacroce, Elona Gaxhja and Marica Colella
Gastrointest. Disord. 2024, 6(2), 431-445; https://doi.org/10.3390/gidisord6020029 - 10 May 2024
Viewed by 564
Abstract
A severe condition of sepsis can be a complication of necrotizing enterocolitis (NEC), which can occur in premature infants and becomes a medical challenge in the neonatal intensive care unit (NICU). It is a multifactorial intestinal disease (can affect both the small and [...] Read more.
A severe condition of sepsis can be a complication of necrotizing enterocolitis (NEC), which can occur in premature infants and becomes a medical challenge in the neonatal intensive care unit (NICU). It is a multifactorial intestinal disease (can affect both the small and large intestine) that can lead to ischemia of the intestinal tissues that evolves into acute organ necrosis. One of these factors is that different types of nutrition can influence the onset or the progression of the disease. Cow-milk-based infant formulas have been shown to cause it in premature infants more frequently than human milk. Recently, nutrition has been shown to be beneficial after surgery. Several issues still under study, such as the pathogenesis and the insufficient and often difficult therapeutic approach, as well as the lack of a common and effective prevention strategy, make this disease an enigma in daily clinical practice. Recent studies outlined the emerging role of the host immune system and resident gut microbiota, showing their close connection in NEC pathophysiology. In its initial stages, broad-spectrum antibiotics, bowel rest, and breastfeeding are currently used, as well as probiotics to help the development of the intestinal microbiota and its eubiosis. This paper aims to present the current knowledge and potential fields of research in NEC pathophysiology and therapeutic assessment. Full article
(This article belongs to the Special Issue Factors Affecting Disease Activity in Children and Adults with Inflammatory Bowel Disease: An Exploration of Pro-Inflammatory and Anti-Inflammatory Elements)
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