Animal Models for Human Diseases: Advances in Genome Editing
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".
Deadline for manuscript submissions: 20 October 2024 | Viewed by 661
Special Issue Editor
Special Issue Information
Dear Colleagues,
Animal models of human diseases are essential for understanding disease mechanisms and developing new treatments. Animal models are often selected because of their similarity to humans in terms of genetics, anatomy, and physiology. They are also often preferable for experimental disease research because of their unlimited supply and ease of manipulation. Genome editing technologies, such as CRISPR-Cas9, have revolutionized the creation of animal models by allowing for precise and efficient genetic modifications. This has enabled the development of new models of a wide range of human diseases, including genetic disorders, cancer, and infectious diseases.
Animal models generated using genome editing have several advantages over traditional models. First, they can be designed to recapitulate the genetic and phenotypic features of human diseases with greater accuracy. Second, they can be used to study the effects of genetic mutations on different tissues and organs. Third, they can be used to screen new drugs and therapies in a preclinical setting.
As genome editing technology continues to improve, we can expect to see even more sophisticated and informative models being developed. This will help us to better understand human diseases and develop new and more effective treatments.
This Special Issue will cover all aspects of modelling human diseases in various animal species via genome editing, present recent developments of novel transgenic tools and their applications and provide validation that such models can be successfully used in biomedical research.
Dr. Andrei Golovko
Guest Editor
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- genome editing
- CRISPR-Cas9
- disease models
- genetic modifications
- knockout
- knock-in
- indel
- point mutation
- phenotype
