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Clinical Management of Osteoporotic Fractures
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Clinical Management of Osteoporotic Fractures

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Orthopedics".

Deadline for manuscript submissions: closed (15 July 2022) | Viewed by 4602

Special Issue Editors

Dr. Hiroyuki Inose

E-Mail Website
Guest Editor
Department of Orthopaedic Surgery, Tokyo Medical and Dental University, Tokyo, Japan
Interests: osteoporotic fractures; spinal surgery
Dr. Shinji Takahashi

E-Mail Website
Guest Editor
Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan
Interests: osteoporosis; spine surgery; vertebral fracture; spinal alignment; adult spinal deformity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The medical and social impact of osteoporotic fractures has become increasingly notable with the advent of an aging society accompanied by recent advances in medicine. Osteoporotic fractures cause deterioration in patients’ quality of life and activities of daily living and have recently been reported to increase the risk of death.

However, there are still various unresolved problems in the prevention, diagnosis, conservative treatment, and surgical treatment of osteoporotic fractures; for example, the usefulness of braces has not been established for fresh osteoporotic vertebral fractures, and the appropriate duration of bracing remains unclear. Osteoporotic fractures can lead to serious social problems and huge economic losses if not properly managed. Therefore, it is very important to gain detailed knowledge about the prevention, diagnosis, and treatment of osteoporotic fractures.

This Special Issue, "Clinical Management of Osteoporotic Fractures", aims to provide an updated overview of the prevention, diagnosis, and treatment of osteoporotic fractures. This Special Issue covers not only vertebral fractures but also fractures of the extremities. We invite researchers to submit original research and review articles on the management of osteoporotic fractures.

Dr. Hiroyuki Inose
Dr. Shinji Takahashi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • human
  • osteoporosis
  • etiology
  • pathogenesis
  • diagnosis
  • conservative treatment
  • surgical treatment

Published Papers (3 papers)

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Research

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10 pages, 1174 KiB  
Article
Associations between Abdominal Trunk Muscle Weakness and Future Osteoporotic Vertebral Fracture in Middle-Aged and Older Adult Women: A Three-Year Prospective Longitudinal Cohort Study
by Satoshi Kato, Satoru Demura, Kazuya Shinmura, Noriaki Yokogawa, Yuki Kurokawa, Ryohei Annen, Motoya Kobayashi, Yohei Yamada, Satoshi Nagatani, Hidenori Matsubara, Tamon Kabata and Hiroyuki Tsuchiya
J. Clin. Med. 2022, 11(16), 4868; https://doi.org/10.3390/jcm11164868 - 19 Aug 2022
Viewed by 1305
Abstract
Potential risk factors associated with future osteoporotic vertebral fracture (OVF) were prospectively investigated in middle-aged and older adult women. We enrolled 197 female patients aged ≥50 years who were scheduled to undergo surgery for lower-extremity degenerative diseases. Patient anthropometric and muscle strength measurements, [...] Read more.
Potential risk factors associated with future osteoporotic vertebral fracture (OVF) were prospectively investigated in middle-aged and older adult women. We enrolled 197 female patients aged ≥50 years who were scheduled to undergo surgery for lower-extremity degenerative diseases. Patient anthropometric and muscle strength measurements, a bone mineral density measurement of the lumbar spine (L-BMD), and full-spine standing radiographs to examine the presence of old OVFs and spinopelvic sagittal parameters were obtained preoperatively. We evaluated 141 patients who underwent full-spine standing radiographs three years postoperatively to identify new OVFs. We excluded 54 patients who did not undergo a second radiographic examination and 2 with new traumatic OVFs. Univariate and multivariate analyses were performed to identify risk factors associated with new non-traumatic OVF occurrence. Ten (7.1%) patients developed new non-traumatic OVFs during the study period (fracture group). The fracture group had less abdominal trunk muscle strength, lower L-BMD, smaller sacral slopes, and larger pelvic tilt than the non-fracture group. The fracture group showed a higher prevalence of old OVFs preoperatively than the non-fracture group. Abdominal trunk muscle weakness, low L-BMD, and the presence of old OVFs were identified as significant risk factors for OVF occurrence. In middle-aged or older adult women, abdominal trunk muscle weakness, low L-BMD, and old OVFs were associated with future OVF. Full article
(This article belongs to the Special Issue Clinical Management of Osteoporotic Fractures)
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9 pages, 1060 KiB  
Article
Factors Contributing to Residual Low Back Pain after Osteoporotic Vertebral Fractures
by Hiroyuki Inose, Tsuyoshi Kato, Shoichi Ichimura, Hiroaki Nakamura, Masatoshi Hoshino, Shinji Takahashi, Daisuke Togawa, Toru Hirano, Yasuaki Tokuhashi, Tetsuro Ohba, Hirotaka Haro, Takashi Tsuji, Kimiaki Sato, Yutaka Sasao, Masahiko Takahata, Koji Otani, Suketaka Momoshima, Takashi Hirai, Toshitaka Yoshii and Atsushi Okawa
J. Clin. Med. 2022, 11(6), 1566; https://doi.org/10.3390/jcm11061566 - 12 Mar 2022
Cited by 4 | Viewed by 1819
Abstract
Although osteoporotic vertebral fractures (OVFs) are the most common type of osteoporotic fracture, few reports have investigated the factors contributing to residual low back pain in the chronic phase after OVFs by using radiographic evaluation. We examined the contribution of nonunion, vertebral deformity, [...] Read more.
Although osteoporotic vertebral fractures (OVFs) are the most common type of osteoporotic fracture, few reports have investigated the factors contributing to residual low back pain in the chronic phase after OVFs by using radiographic evaluation. We examined the contribution of nonunion, vertebral deformity, and thoracolumbar alignment to the severity of residual low back pain post-OVF. This post hoc analysis of a prospective randomized study included 195 patients with a 48-week follow-up period. We investigated the associations between radiographic variables with the visual analog scale (VAS) scores for low back pain at 48 weeks post-OVF using a multiple linear regression model. Univariate analysis revealed that analgesic use, the local angle on magnetic resonance imaging, anterior vertebral body compression percentage on X-ray, and nonunion showed a significant association with VAS scores for low back pain. Multiple regression analysis produced the following equation: VAS for low back pain at 48 weeks = 15.49 + 0.29 × VAS for low back pain at 0 weeks + (with analgesics: +8.84, without analgesics: −8.84) + (union: −5.72, nonunion: −5.72). Among local alignment, thoracolumbar alignment, and nonunion, nonunion independently contributed to residual low back pain at 48 weeks post-OVF. A treatment strategy that reduces the occurrence of nonunion is desirable. Full article
(This article belongs to the Special Issue Clinical Management of Osteoporotic Fractures)
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Review

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12 pages, 459 KiB  
Review
Association between Immediate Postoperative Radiographic Findings and Failed Internal Fixation for Trochanteric Fractures: Systematic Review and Meta-Analysis
by Norio Yamamoto, Yasushi Tsujimoto, Suguru Yokoo, Koji Demiya, Madoka Inoue, Tomoyuki Noda, Toshifumi Ozaki and Takashi Yorifuji
J. Clin. Med. 2022, 11(16), 4879; https://doi.org/10.3390/jcm11164879 - 19 Aug 2022
Cited by 6 | Viewed by 2307
Abstract
Failed internal fixations for trochanteric fractures have a strong negative impact owing to increased postoperative mortality and high medical costs. However, evidence on the prognostic value of postoperative radiographic findings for failed internal fixations is limited. We aimed to clarify the association between [...] Read more.
Failed internal fixations for trochanteric fractures have a strong negative impact owing to increased postoperative mortality and high medical costs. However, evidence on the prognostic value of postoperative radiographic findings for failed internal fixations is limited. We aimed to clarify the association between comprehensive immediate postoperative radiographic findings and failed internal fixation using relative and absolute risk measures. We followed the meta-analysis of observational studies in epidemiology guidelines and the Cochrane handbook. We searched specific databases in November 2021. The outcomes of interest were failed internal fixation and cut-out. We pooled the odds ratios and 95% confidence intervals using a random-effects model and calculated the number needed to harm for each outcome. Thirty-six studies involving 8938 patients were included. The certainty of evidence in the association between postoperative radiographic findings and failed internal fixation or cut-out was mainly low or very low except for the association between intramedullary malreduction on the anteromedial cortex and failed internal fixation. Moderate certainty of evidence supported that intramedullary malreduction on the anteromedial cortex was associated with failed internal fixation. Most postoperative radiographic findings on immediate postoperative radiographs for trochanteric fractures were uncertain as prognostic factors for failed internal fixations. Full article
(This article belongs to the Special Issue Clinical Management of Osteoporotic Fractures)
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