New Insights into the Placental and Placental Membrane Pathophysiology of Preterm Birth Version 2.0
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Reproductive and Developmental Biology".
Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 1713
Special Issue Editor
Interests: preterm birth; preterm labor; preterm-PROM; fetal growth restriction; placenta; feto-maternal interface; ascending intrauterine infection; intra-amniotic inflammation; chorioamnionitis; maternal vascular malperfusion; fetal vascular malperfusion; neonatal morbidity
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Special Issue Information
Dear Colleagues,
Preterm birth is a leading cause of perinatal morbidity and mortality. Unfortunately, preterm births continue unabated despite the rapid progress of medical science. To resolve this matter for the future, it is essential to determine the exact pathophysiology of the placenta in preterm birth.
Preterm birth is divided into spontaneous preterm birth (due to preterm labor and intact membranes and the preterm premature rupture of membranes) and indicated preterm birth (due to preeclampsia and idiopathic fetal growth restriction). Ascending intrauterine infection and subsequent acute histologic chorioamnionitis (i.e., a maternal inflammatory response in the placenta; inflammation in extraplacental membranes and the chorionic plate) and/or fetal inflammation (i.e., a fetal inflammatory response in the placenta; inflammation in the umbilical cord and chorionic vessels) are known to be among the central pathophysiologies in spontaneous preterm birth.
Utero–placental insufficiency (i.e., maternal vascular malperfusion and fetal vascular malperfusion in the placenta) is an important pathophysiology in preeclampsia and idiopathic fetal growth restriction.
Meticulous research on the histopathology and molecular pathology (i.e., immunohistochemistry and transcriptomic analysis) in the placenta and placental membrane of preterm birth will provide us with the basis for the prevention and treatment of numerous patients at risk of preterm birth.
This Special Issue aims to present new insights in the field, covering areas ranging from histopathology to molecular pathology in the placenta and placental membrane of preterm birth. We welcome original research articles and reviews on the placental pathophysiology of preterm birth.
Dr. Chan-Wook Park
Guest Editor
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Keywords
- preterm birth
- placenta
- fetal membranes
- feto–maternal interface
- chorioamnionitis
- ascending intrauterine infection
- fetal vascular malperfusion
- maternal vascular malperfusion
- neonatal morbidity
- preterm labor
- preterm-PROM
- preeclampsia
- fetal growth restriction
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