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Nanomaterials for Advanced Biomedical Applications, 2nd Edition

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Special Issue Editors

Special Issue Information

Dear Colleagues,

Over recent decades, there has been intense scientific interest in the discovery of various types of nanomaterials and their potential biomedical applications. One reason for this interest is that nanomaterials exhibit innovative, remarkable, and beneficial physical, chemical, and biological characteristics compared to conventional materials. Parameters that are central to these characteristics include nanostructure shape, particle size, surface charge, and surface area, because they affect the biocharacteristics and performance of nanomaterials. Current trends in the literature show that there is still a lack of research focusing on the production and formulation of nanomaterials, providing opportunities for future advanced medical and pharmaceutical applications.

Consequently, the Special Issue “Nanomaterials for Advanced Biomedical Applications, 2nd Edition” aims to showcase in-depth discussions of the most recent progress in nanomaterials, not only in the preparation methods/instruments and characterization tools but also in their promising biomedical applications. This Special Issue welcomes original research articles and reviews, with research topics covering all types of nanomaterial formulations for biomedical applications.

Topics of interest include, but are not limited to, the following:

Novel methods for the synthesis of nanomaterials for biomedical applications;
Synthesis and characterization of composite-based nanomaterials for biomedical applications;
Green synthesis of metal nanoparticles and their biomedical applications;
Bio-active-agent-based nanomaterials;
Inorganic nanostructures, including nanoparticles, nanofibers, nanowires, nanorods, etc.;
Smart nanomaterials for biomedical applications;
Nanomaterials for tissue engineering and wound healing;
Nanomaterials for targeted and controlled drug delivery systems (DDSs);
Polymer nanocomposites for advanced biomedical applications;
Carbon-based nanomaterials for biomedical applications.

Dr. Zyta M. Ziora
Dr. Ahmed M. Omer
Guest Editors

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Related Special Issue

Published Papers (1 paper)

Review

23 pages, 3033 KiB

Open AccessReview

Recent Advancements in Metallic Au- and Ag-Based Chitosan Nanocomposite Derivatives for Enhanced Anticancer Drug Delivery

by Mahmoud A. El-Meligy, Eman M. Abd El-Monaem, Abdelazeem S. Eltaweil, Mohamed S. Mohy-Eldin, Zyta M. Ziora, Abolfazl Heydari and Ahmed M. Omer

Molecules 2024, 29(10), 2393; https://doi.org/10.3390/molecules29102393 - 19 May 2024

Viewed by 505

Abstract

The rapid advancements in nanotechnology in the field of nanomedicine have the potential to significantly enhance therapeutic strategies for cancer treatment. There is considerable promise for enhancing the efficacy of cancer therapy through the manufacture of innovative nanocomposite materials. Metallic nanoparticles have been found to enhance the release of anticancer medications that are loaded onto them, resulting in a sustained release, hence reducing the dosage required for drug administration and preventing their buildup in healthy cells. The combination of nanotechnology with biocompatible materials offers new prospects for the development of advanced therapies that exhibit enhanced selectivity, reduced adverse effects, and improved patient outcomes. Chitosan (CS), a polysaccharide possessing distinct physicochemical properties, exhibits favorable attributes for controlled drug delivery due to its biocompatibility and biodegradability. Chitosan nanocomposites exhibit heightened stability, improved biocompatibility, and prolonged release characteristics for anticancer medicines. The incorporation of gold (Au) nanoparticles into the chitosan nanocomposite results in the manifestation of photothermal characteristics, whereas the inclusion of silver (Ag) nanoparticles boosts the antibacterial capabilities of the synthesized nanocomposite. The objective of this review is to investigate the recent progress in the utilization of Ag and Au nanoparticles, or a combination thereof, within a chitosan matrix or its modified derivatives for the purpose of anticancer drug delivery. The research findings for the potential of a chitosan nanocomposite to deliver various anticancer drugs, such as doxorubicin, 5-Fluroacil, curcumin, paclitaxel, and 6-mercaptopurine, were investigated. Moreover, various modifications carried out on the chitosan matrix phase and the nanocomposite surfaces to enhance targeting selectivity, loading efficiency, and pH sensitivity were highlighted. In addition, challenges and perspectives that could motivate further research related to the applications of chitosan nanocomposites in cancer therapy were summarized. Full article

(This article belongs to the Special Issue Nanomaterials for Advanced Biomedical Applications, 2nd Edition)

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