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Natural Deep Eutectic Solvents and Other Green Solvents: The New Lights for Extraction and Valorization of Bioactive Phytochemical Compounds

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Green Chemistry".

Deadline for manuscript submissions: 31 October 2024 | Viewed by 663

Special Issue Editors


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Guest Editor
Department of Pharmaceutical Botany, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand
Interests: natural products; medicinal plants; flavonoids; pharmacological activities; anti-aging; cosmeceuticals; nutricosmetics; phytopharmaceutical products
Special Issues, Collections and Topics in MDPI journals

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Co-Guest Editor
Institute of Bast Fiber Crops and Center of Southern Economic Crops, Chinese Academy of Agricultural Sciences, Changsha 410205, China
Interests: bioactive ingredients in food resources; food packaging; food preservation; biodegradable materials; green solvents; deep eutectic solvents; ionic liquids; bio-based solvents; solid–liquid extraction; liquid–liquid extraction
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In today’s era of green chemistry and environmentally friendly product development, green solvents are continuously developed to extract and valorize bioactive molecules from natural products, especially plants, and widely applied in cosmetic and pharmaceutical product development.

The application of natural deep eutectic solvents (NaDESs) and many other green solvents is of particular interest. These are promising alternative organic solvents that are suitable for green extraction due to their environmentally friendly impact, high flash points with low toxicity, high solvency, and biodegradability. These solvents can also be obtained from renewable resources, which makes them as easy to recycle and helpful for reducing the cost of developing cosmetics and pharmaceuticals.

Our Special Issue welcomes all potential authors to contribute their original research and/or review articles focusing on the latest research developments and innovations in natural deep eutectic solvents (NaDESs) and other green solvents for the extraction and valorization of bioactive phytochemical compounds for cosmetic and pharmaceutical product applications.

Dr. Duangjai Tungmunnithum
Dr. Zhijian Tan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • green solvents
  • NaDES
  • extraction
  • valorization
  • bioactive phytochemical compounds

Published Papers (1 paper)

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Research

20 pages, 4471 KiB  
Article
Ultrasound-Assisted Extraction of Phenolic Compounds from Celtuce (Lactuca sativa var. augustana) Leaves Using Natural Deep Eutectic Solvents (NADES): Process Optimization and Extraction Mechanism Research
by Shanshan Li, Guangyu Wang, Junjie Zhao, Penghui Ou, Qingping Yao and Wei Wang
Molecules 2024, 29(10), 2385; https://doi.org/10.3390/molecules29102385 - 19 May 2024
Viewed by 385
Abstract
Natural deep eutectic solvents (NADESs), as emerging green solvents, can efficiently extract natural products from natural resources. However, studies on the extraction of phenolic compounds from celtuce (Lactuca sativa var. augustana) leaves (CLs) by NADESs are still lacking. This study screened [...] Read more.
Natural deep eutectic solvents (NADESs), as emerging green solvents, can efficiently extract natural products from natural resources. However, studies on the extraction of phenolic compounds from celtuce (Lactuca sativa var. augustana) leaves (CLs) by NADESs are still lacking. This study screened the NADES L-proline-lactic acid (Pr-LA), combined it with ultrasound-assisted extraction (UAE) to extract phenolic compounds from CLs, and conducted a comparative study on the extraction effect with traditional extraction solvents. Both SEM and FT-IR confirmed that Pr-LA can enhance the degree of fragmentation of cell structures and improve the extraction rate of phenolic compounds. Molecular dynamics simulation results show that Pr-LA can improve the solubility of phenolic compounds and has stronger hydrogen bonds and van der Waals interactions with phenolic compounds. Single-factor and Box–Behnken experiments optimized the process parameters for the extraction of phenolic compounds from CLs. The second-order kinetic model describes the extraction process of phenolic compounds from CLs under optimal process parameters and provides theoretical guidance for actual industrial production. This study not only provides an efficient and green method for extracting phenolic compounds from CLs but also clarifies the mechanism of improved extraction efficiency, which provides a basis for research on the NADES extraction mechanism. Full article
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