Molecular Epidemiology of Emerging Viruses

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Emerging Pathogens".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 704

Special Issue Editor


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Guest Editor
Department of Exact and Earth Sciences, University of the State of Bahia, Salvador 41150-000, Brazil
Interests: bioinformatics; viral evolution; molecular epidemiology; mathematical models; phylogenetic and phylodynamic trees
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In the ever-evolving landscape of infectious diseases, the study of emerging viruses stands at the forefront of scientific inquiry. As the global community grapples with the challenges posed by novel viral threats, the need for a comprehensive understanding of their molecular epidemiology becomes increasingly paramount. We are pleased to announce a Special Issue of Pathogens entitled "Molecular Epidemiology of Emerging Viruses". In this Special Issue, we aim to provide new genomic and epidemiological data on viral strains circulating worldwide and offer an overview of the real-time global evolution of viruses.

This Special Issue invites contributions, welcoming original research articles, reviews, and methodological papers that span a broad spectrum of themes, including bioinformatics in viral research, viral evolution and dynamics, epidemiological investigations, mathematical models for emerging and recurrent viruses, and other topics related to the molecular epidemiology of emerging viruses.

Please feel free to submit your contributions, as we aim to create a comprehensive collection that advances our understanding of the intricate dynamics of emerging viruses. Manuscripts should adhere to the guidelines outlined by the journal and be submitted through the online platform.

Dr. Vagner Fonseca
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • emerging viruses
  • molecular epidemiology
  • genomic data
  • genome evolution
  • viral evolution
  • epidemiological investigations
  • bioinformatics
  • mathematical models
  • phylogenetic and phylodynamic trees

Published Papers (1 paper)

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Research

13 pages, 2078 KiB  
Article
High Frequencies of kdr Mutation and Chikungunya Infection in Aedes aegypti Population from Minas Gerais, Brazil
by Pedro Augusto Almeida-Souza, Cirilo Henrique de Oliveira, Luiz Paulo Brito, Thaynara de Jesus Teixeira, Iago Alves Celestino, Gabriele Barbosa Penha, Ronaldo Medeiros dos Santos, Wexley Miranda Mendes, Bergmann Morais Ribeiro, Fabrício Souza Campos, Paulo Michel Roehe, Natalia Rocha Guimarães, Felipe C. M. Iani, Ademir Jesus Martins and Filipe Vieira Santos de Abreu
Pathogens 2024, 13(6), 457; https://doi.org/10.3390/pathogens13060457 - 28 May 2024
Viewed by 554
Abstract
The Chikungunya virus (CHIKV) presents global health challenges, with Brazil experiencing outbreaks since its introduction in 2014. In 2023, following a CHIKV outbreak in Minas Gerais (MG), social media was used to optimize an entomological survey aimed at identifying vectors and viral lineages [...] Read more.
The Chikungunya virus (CHIKV) presents global health challenges, with Brazil experiencing outbreaks since its introduction in 2014. In 2023, following a CHIKV outbreak in Minas Gerais (MG), social media was used to optimize an entomological survey aimed at identifying vectors and viral lineages and assessing insecticide resistance. Following Instagram posts, residents with suspected CHIKV infection were able to schedule mosquito aspirations. In total, 421 mosquitoes (165 Aedes aegypti and 256 Culex quinquefasciatus) were captured from 40 households in Salinas city (MG) and tested for the Dengue, Zika, and Chikungunya viruses through RT-qPCR. Twelve of 57 pools (10 Ae. aegypti and two Cx. quinquefasciatus) tested positive for CHIKV RNA. Viral RNA was also detected in the heads of nine Ae. aegypti, indicating viral dissemination but not in Cx. quinquefasciatus. Genome sequencing yielded the first near-complete genome from the 2023 outbreak, unveiling that the CHIKV strain belonged to the East/Central/South African (ECSA) genotype. Additionally, genetic analyses revealed high frequencies of kdr alleles, including in CHIKV-infected mosquitoes, suggesting resistance to pyrethroid insecticides in this Ae. aegypti population. Social media was important for guiding mosquito-capture efforts in CHIKV transmission hotspots, thus optimizing the opportunity for viral detection. These findings emphasize the urgent need for innovative vector studies and control strategies, as well as interdisciplinary approaches in public health interventions. Full article
(This article belongs to the Special Issue Molecular Epidemiology of Emerging Viruses)
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