The 20th Anniversary of Pharmaceuticals: Advances in Peptide Drug Design and Development: From Sequences to Drug Candidates
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Biopharmaceuticals".
Deadline for manuscript submissions: 30 June 2024 | Viewed by 1226
Special Issue Editors
Interests: medicinal chemistry; drug discovery and development; G protein-coupled receptors; drug optimization; GPCR signaling; biased signaling; allosteric modulators
Interests: peptide-based drugs; peptide chemistry; G protein-coupled receptors; pharmacology; cardiovascular pharmacology; allosteric modulators; biased agonists
Special Issue Information
Dear Colleagues,
The upcoming Special Issue "Advances in Peptide Drug Design and Development: from Sequences to Drug Candidates" will explore the research landscape of peptide-based bioactive molecules. Peptides have emerged as versatile motifs to be explored in the drug discovery and development research field, offering unique advantages such as target specificity and low toxicity compared to small molecule counterparts. This Special Issue aims to showcase recent advances in peptide engineering, highlighting strategies such as identifying promising peptide sequences as well as translating them into viable drug candidates.
We invite researchers in the drug development research field, medicinal chemistry, pharmacology, physiology, molecular biology, and clinicians to contribute their original research findings as well as insights and perspectives on the current trends and challenges in designing peptide-based drug candidates.
The key areas to be addressed include:
- Peptide Sequencing and Screening: Identification of biologically active peptide sequences and essential pharmacophore motifs.
- Peptide Modifications and Engineering: Cutting-edge strategies for optimizing sequences to enhance the stability, bioavailability, pharmacokinetics, and pharmacological properties of peptides.
- Structural Insights: Exploring the impact of tridimensional structures on peptide activity, employing NMR spectroscopy data, and computational models.
- Peptide Synthesis: Advances in synthesis techniques, including solid-phase and microwave-assisted methods, orthogonal chemistry, and late-stage modifications.
- Bioconjugation and Drug Delivery: Development of peptide–drug conjugates and strategies for targeted delivery and controlled release.
- Peptide-Based Therapeutics: Case studies characterizing the pharmacological properties of peptide-based therapeutics, from in vitro to clinical settings.
- Toxicology and Safety Assessment: Methodologies for and challenges in evaluating safety, toxicity, and the immunogenicity of peptide-based drug candidates.
- Emerging Technologies: Exploration of innovative technologies, such as mRNA-encoding peptides, CRISPR-mediated therapies, and AI-driven drug design.
- Future Perspectives: Insights into the evolving landscape of peptide drug development, including personalized medicine, combination therapies, and addressing unmet medical needs.
Dr. Juliana C. C. Dallagnol
Prof. Dr. David Chatenet
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- peptide-based drugs
- drug design
- therapeutic peptides
- peptide synthesis
- structure–activity relationship
- peptide drug delivery
- bioavailability
- formulation strategies
- peptide therapeutics
