Cardiovascular Diseases: Where Do We Stand with Human-Derived Stem Cells?

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Biopharmaceuticals".

Deadline for manuscript submissions: 10 September 2024 | Viewed by 1403

Special Issue Editors


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Guest Editor
Institute of Physiology I, University of Bonn, Nußallee 11, 53115 Bonn, Germany
Interests: cardiovascular physiology; cardiomyocytes; hiPSC-derived cardiomyocytes; patch clamp; GPCR signaling

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Guest Editor
Department of Life Sciences and Systems Biology, University of Turin, Via Accademia Albertina 13, 10123 Turin, Italy
Interests: cardiovascular physiology,; cardiomyocytes; hiPSC-derived cardiomyocytes; cellular metabolism; cardioprotection

Special Issue Information

Dear Colleagues,

The treatment of cardiac and vascular outcomes is becoming an intriguing global target due to the high morbidity and mortality related to these pathological conditions.

In addition to drug treatments that have produced significant results in preventing and treating cardiovascular diseases, the personalized medicine approach seems to be a great opportunity for clinical intervention.

In this scenario, human induced pluripotent stem cells (hiPSC) represent a possible tool to be used in a two-way approach: first, in regenerative medicine, particularly those conditions related to the loss of heart function, and second, as a cellular model able to be used instead of animals, which are important models for drug study and application, but, unfortunately, still far from humans. 

This Special Issue aims to present discoveries in the differentiation procedures, function, and physiological and metabolic characterization of hiPSC-derived cells, focusing on their use in treating cardiovascular diseases or drug screening.

Original research papers, critical up-to-date articles, and reviews on the potential use of hiPSC in cardiac and vascular pathologies are welcome. 

Dr. Daniela Malan
Dr. Giulia Querio
Guest Editors

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Keywords

  • hiPSC
  • regenerative medicine
  • personalized medicine
  • cardiovascular disease

Published Papers (1 paper)

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Review

26 pages, 2197 KiB  
Review
Differentiation of Pluripotent Stem Cells for Disease Modeling: Learning from Heart Development
by Congwu Chi, Truman J. Roland and Kunhua Song
Pharmaceuticals 2024, 17(3), 337; https://doi.org/10.3390/ph17030337 - 5 Mar 2024
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Abstract
Heart disease is a pressing public health problem and the leading cause of death worldwide. The heart is the first organ to gain function during embryogenesis in mammals. Heart development involves cell determination, expansion, migration, and crosstalk, which are orchestrated by numerous signaling [...] Read more.
Heart disease is a pressing public health problem and the leading cause of death worldwide. The heart is the first organ to gain function during embryogenesis in mammals. Heart development involves cell determination, expansion, migration, and crosstalk, which are orchestrated by numerous signaling pathways, such as the Wnt, TGF-β, IGF, and Retinoic acid signaling pathways. Human-induced pluripotent stem cell-based platforms are emerging as promising approaches for modeling heart disease in vitro. Understanding the signaling pathways that are essential for cardiac development has shed light on the molecular mechanisms of congenital heart defects and postnatal heart diseases, significantly advancing stem cell-based platforms to model heart diseases. This review summarizes signaling pathways that are crucial for heart development and discusses how these findings improve the strategies for modeling human heart disease in vitro. Full article
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