Advances in Phototherapy and Sonodynamic Therapy, 2nd Edition

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: 20 July 2024 | Viewed by 779

Special Issue Editors


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Guest Editor
Center for General Education, Chang Gung University, Taoyuan 333, Taiwan
Interests: nanoformulations; molecular imaging; nanoprobes; theranostic strategy; nanomedicine
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Faculty of Chemistry, Jagielllonian University, Gronostajowa 2, 30-387 Kraków, Poland
Interests: nano/microstuctural drug carriers; polymeric drugs; controlled release; theranostics; antiviral angents; antibacterial systems; novel drugs for photodynamic therapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nanomaterial-mediated photo and sonodynamic therapeutic cancer treatments provide significant hope for enhancing patients’ quality of life. Phototherapy is a prominent non-invasive treatment modality in which nanomaterials absorb incident light and generate thermal heat (to mediate photothermal therapy—PTT) and cytotoxic reactive oxygen species (to mediate photodynamic therapy—PDT), allowing them to tackle tumors efficiently in both in vitro and in vivo models. Meanwhile, sonodynamic therapy (SDT) leverages sonosensitizers exposed to low-intensity ultrasound for tumor ablation.

Both of these therapeutic modalities have unique advantages, such as minimal invasiveness, spatiotemporal controllability, deep tissue penetration, a short recovery period, etc. Moreover, the flexibility of biomaterials allows phototherapy/SDT to be combined with other imaging tools (MRI, CT, fluorescence)/cancer treatments (chemo, radio, immuno, etc.) for synergistic therapeutic/theranostic effects, further improving therapeutic outcomes.

This Special Issue of Pharmaceutics will focus on the advances in nanomaterial-mediated photo/sonodymic approaches (including, but not limited to, phototherapy, photodynamic therapy, sonodynamic therapy, theranostic platforms) used to combat cancer. High-quality quality research papers, reviews, and are welcome.

We look forward to receiving your submissions.

Prof. Dr. Chia-Hao Su
Prof. Dr. Maria Nowakowska
Guest Editors

Manuscript Submission Information

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Keywords

  • photothermal therapy
  • photodynamic therapy
  • sonodynamic therapy
  • nanomaterials
  • theranostics
  • synrgestic therapy
  • combination therapy

Published Papers (1 paper)

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Research

12 pages, 225 KiB  
Article
Efficacy and Safety of 5-Aminolevulinic Acid Photodynamic Therapy for Treating Cervical and Vaginal Intraepithelial Neoplasia
by Qin Han, Hongyan Guo, Zhangxin Wu, Jiaxin Shi and Xue Zhang
Pharmaceutics 2024, 16(5), 627; https://doi.org/10.3390/pharmaceutics16050627 - 7 May 2024
Viewed by 332
Abstract
Persistent HPV infections may cause cervical and vaginal intraepithelial neoplasia (CIN and VaIN). Traditional methods might destroy the structure and function of the cervix. 5-aminolevulinic acid photodynamic therapy (ALA-PDT) is a non-invasive targeted therapy. This study aims to evaluate the efficacy and safety [...] Read more.
Persistent HPV infections may cause cervical and vaginal intraepithelial neoplasia (CIN and VaIN). Traditional methods might destroy the structure and function of the cervix. 5-aminolevulinic acid photodynamic therapy (ALA-PDT) is a non-invasive targeted therapy. This study aims to evaluate the efficacy and safety of ALA-PDT for CIN and VaIN and the clearance of HPV. A retrospective study of 303 patients who confirmed CIN or VaIN and received ALA-PDT was conducted. All the patients were followed up at six and twelve months after treatment and then annually thereafter. The effect was evaluated through HPV genotyping, a cytology test, and colposcopy-directed biopsy if necessary. After ALA-PDT, the remission rates for CIN 2, CIN 3, VaIN 2, and VaIN 3 were 90.6%, 88.5%, 87.3%, and 77.8%. For CIN 1, the remission rate at the six-month follow-up was 93.1%. The total HPV clearance rates were 72.5% at the six-month follow-up and 85.7% at the 12-month follow-up. The most common adverse event was vaginal discharge. No severe adverse effect was observed. ALA-PDT is an effective and safe treatment for all grades of CIN and VaIN and is helpful in clearing HPV with minimal side effects. This treatment may not influence fertility and delivery. Full article
(This article belongs to the Special Issue Advances in Phototherapy and Sonodynamic Therapy, 2nd Edition)
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